Volume 10 Issue 2
Mar.  2019
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Wang Chang, Chen Lizhong, Qiu Jiang, et al. Analysis of 11 cases of ABO incompatible living kidney transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011
Citation: Wang Chang, Chen Lizhong, Qiu Jiang, et al. Analysis of 11 cases of ABO incompatible living kidney transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011
shu

Analysis of 11 cases of ABO incompatible living kidney transplantation

doi: 10.3969/j.issn.1674-7445.2019.02.011

  • Department of Organ Transplantation, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China

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  • Corresponding author: Chen Guodong, Email: chenguodong2000@163.com
  • Received Date: 2019-01-08
    Available Online: 2021-04-27
  • Publish Date: 2019-03-15
    Abstract
  •   Objective  To evaluate the clinical efficacy and safety of ABO incompatible living kidney transplantation(ABOi-KT).  Methods  Clinical data of 11 donors and recipients with ABOi-KT were retrospectively analyzed. All the recipients were treated with desensitization before operation. The recovery condition of renal function and blood type antibody titer of the ABOi-KT recipients were monitored after operation. The incidence of complications and clinical prognosis of ABOi-KT recipients were observed.  Results  The serum creatinine (Scr) of 11 recipients were well recovered after ABOi-KT. No delay in recovery of graft renal function. Among them, 2 recipients experienced a significant increase in the Scr level at postoperative 14 and 45 d respectively, 1 recipient showed criticality cellular rejection after operation and 1 recipient presented with elevated Scr level at postoperative 33 d, accompanied by an increase in blood type antibody titer. The condition became stable after corresponding treatment. The remaining 7 recipients obtained normal graft renal function and postoperative blood type antibody titer did not rebound. During postoperative follow-up until November 2018, no recipient died or graft renal failure occurred. The survival rate of the recipient and graft renal was 100%. Among them, 3 patients suffered from postoperative complications, including pulmonary infection, BK viruria and granulocytopenia, which were cured after symptomatic treatment.  Conclusions  ABOi-KT is safe, feasible and yields high long-term clinical efficacy, which can increase the source of living donor kidney and relieve the shortage of donor kidney.

     

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