Correlation analysis between red cell volume distribution width and the mortality rate in ARDS patients after renal transplantation

Yang Min; Liu Hong; She Xingguo; Niu Ying; Wan Qiquan; Zhuang Quan; Peng Bo; Zhu Yi; Li Cai; Ming Yingzi

doi:10.3969/j.issn.1674-7445.2017.04.005

Volume 8 Issue 4

Jul. 2017

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2017 > 8(4): 276-281

Yang Min, Liu Hong, She Xingguo, et al. Correlation analysis between red cell volume distribution width and the mortality rate in ARDS patients after renal transplantation[J]. ORGAN TRANSPLANTATION, 2017, 8(4): 276-281. doi: 10.3969/j.issn.1674-7445.2017.04.005

Citation:

PDF( 863 KB)

Correlation analysis between red cell volume distribution width and the mortality rate in ARDS patients after renal transplantation

doi: 10.3969/j.issn.1674-7445.2017.04.005

Transplantation Center of the Third Xiangya Hospital, Central South University, Changsha 410013, China

More Information

Corresponding author: Ming Yingzi, Email: myz_china@aliyun.com
Received Date: 2017-04-21
Available Online: 2021-01-19
Publish Date: 2017-07-15

Abstract

Abstract

Objective To investigate the correlation between red cell volume distribution width (RDW) and the mortality rate of acute respiratory distress syndrome (ARDS) patients after renal transplantation. Methods Clinical data of 106 ARDS patients undergoing renal transplantation were retrospectively analyzed. According to RDW, all patients were assigned into the normal (≤15.0%, n=68) and increasing RDW groups ( > 15.0%, n=38). Baseline data and the incidence of adverse events were statistically compared between two groups. Kaplan-Meier survival curve was adopted to compare the 50 d-mortality rate between two groups. Cox's proportional hazards regression model was utilized to identify the risk factors of the mortality of ARDS patients. Results Among 106 patients, the 50 d-mortality rate was calculated as 43.4% (46/106). The sequential organ failure assessment (SOFA) score, serum creatinine, hemoglobin and platelet count significantly differed between two groups (all P < 0.05). In the increasing RDW group, the 50 d-mortality rate and the incidence of infectious shock were significantly higher than those in the normal RDW group (both P < 0.05). Kaplan-Meier survival curve demonstrated that the 50 d-mortality rate significantly differed between two groups (P < 0.01). Cox's proportional hazards regression model univariate analysis revealed that hemoglobin level < 100 g/L, serum creatinine > 133 μmol/L, platelet count < 100×10⁹/L, severe ARDS and RDW > 15.0% were the potential risk factors of the 50 d-mortality rate in ARDS patients (all P < 0.05). Multivariate analysis demonstrated that severe ARDS [odd ratio (OR)=12.77, 95% confidence interval (CI) 11.63-15.39, P < 0.001] and RDW > 15.0% (OR=2.01, 95%CI 1.02-3.94, P < 0.043) were the independent risk factors of the 50 d-mortality rate in ARDS patients. Conclusions RDW elevation is correlated with the severity of disease and 50 d-mortality rate in ARDS patients following renal transplantation. RDW can serve as a clinical parameter to predict the prognosis of ARDS patients after renal transplantation.
- Red cell volume distribution width (RDW),
- Acute respiratory distress syndrome (ARDS),
- Renal transplantation,
- Pulmonary infection,
- Prognosis,
- Predictor,
- Organ donation after citizen's death,
- Septicopyemia

FullText(HTML)

References(27)

References

[1]	Shorr AF, Abbott KC, Agadoa LY. Acute respiratory distress syndrome after kidney transplantation: epidemiology, risk factors, and outcomes[J]. Crit Care Med, 2003, 31(5): 1325-1330. doi: 10.1097/01.CCM.0000053645.38356.A6
[2]	Canet E, Osman D, Lambert J, et al. Acute respiratory failure in kidney transplant recipients: a multicenter study[J]. Crit Care, 2011, 15(2): R91. DOI: 10.1186/cc10091.
[3]	Zhang P, Ye Q, Wan Q, et al. Mortality predictors in recipients developing acute respiratory distress syndrome due to pneumonia after kidney transplantation[J]. Ren Fail, 2016, 38(7): 1082-1088. DOI: 10.1080/0886022X.2016.1184938.
[4]	Förhécz Z, Gombos T, Borgulya G, et al. Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state[J]. Am Heart J, 2009, 158(4): 659-666. DOI: 10.1016/j.ahj.2009.07.024.
[5]	Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease[J]. Circulation, 2008, 117(2): 163-168. doi: 10.1161/CIRCULATIONAHA.107.727545
[6]	Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke[J]. J Neurol Sci, 2009, 277(1/2): 103-108. DOI: 10.1016/j.jns.2008.10.024.
[7]	Allen LA, Felker GM, Mehra MR, et al. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure[J]. J Card Fail, 2010, 16(3): 230-238. DOI: 10.1016/j.cardfail.2009.11.003.
[8]	Braun E, Kheir J, Mashiach T, et al. Is elevated red cell distribution width a prognostic predictor in adult patients with community acquired pneumonia?[J]. BMC Infect Dis, 2014, 14: 129. DOI: 10.1186/1471-2334-14-129.
[9]	Ku NS, Kim HW, Oh HJ, et al. Red blood cell distribution width is an independent predictor of mortality in patients with gram-negative bacteremia[J]. Shock, 2012, 38(2): 123-127. DOI: 10.1097/SHK. 0b013e31825e2a85.
[10]	Lee JH, Chung HJ, Kim K, et al. Red cell distribution width as a prognostic marker in patients with community-acquiredpneumonia[J]. Am J Emerg Med, 2013, 31(1): 72-79. DOI: 10.1016/j.ajem.2012.06.004.
[11]	Jo YH, Kim K, Lee JH, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock[J]. Am J Emerg Med, 2013, 31(3): 545-548. DOI: 10.1016/j.ajem.2012.10.017.
[12]	Lorente L, Martín MM, Abreu-González P, et al. Red blood cell distribution width during the first week is associated with severity and mortality in septic patients[J]. PLoS One, 2014, 9(8): e105436. DOI: 10.1371/journal.pone.0105436.
[13]	ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin definition[J]. JAMA, 2012, 307(23): 2526-2533. DOI: 10.1001/jama.2012.5669.
[14]	Sun Q, Liu ZH, Chen J, et al. An aggressive systematic strategy for acute respiratory distress syndrome caused by severe pneumonia after renal transplantation[J]. Transpl Int, 2006, 19(2): 110-116. doi: 10.1111/tri.2006.19.issue-2
[15]	Mao P, Wan QQ, Ye QF. Bacteria isolated from respiratory tract specimens of renal recipients with acute respiratory distress syndrome due to pneumonia: epidemiology and susceptibility of the strains[J]. Transplant Proc, 2015, 47(10): 2865-2869. DOI: 10.1016/j.transproceed.2015.10.034.
[16]	Chu L, Ye QF, Wan QQ, et al. Mortality predictors in acute respiratory distress syndrome renal transplant recipients with ESKAPE/rESKAPE pneumonia[J]. Transplant Proc, 2015, 47(8): 2450-2455. DOI: 10.1016/j.transproceed.2015.08.005.
[17]	邵明杰, 叶启发, 明英姿, 等.心脏死亡供体的移植肾功能延迟恢复的危险因素分析[J].中南大学学报(医学版), 2012, 37(10): 1045-1049. DOI: 10.3969/j.issn.1672-7347.2012.10.013. Shao MJ, Ye QF, Ming YZ, et al. Delayed graft function after DCD kidney transplantation: risk factors for and impact on transplantation[J]. J Cent South Univ(Med Sci), 2012, 37(10): 1045-1049. DOI: 10.3969/j.issn.1672-7347.2012.10.013.
[18]	Zhao W, Ge X, Sun K, et al. Acute respiratory distress syndrome after orthotopic liver transplantation[J]. J Crit Care, 2016, 31(1): 163-167. DOI: 10.1016/j.jcrc.2015.09.028.
[19]	Huang R, Yang C, Wu K, et al. Red cell distribution width as a potential index to assess the severity of hepatitis B virus-related liver diseases[J]. Hepatol Res, 2014, 44(14): E464-E470. DOI: 10.1111/hepr.12342.
[20]	Clarke K, Sagunarthy R, Kansal S. RDW as an additional marker in inflammatory bowel disease/undifferentiated colitis[J]. Dig Dis Sci, 2008, 53(9): 2521-2523. DOI: 10.1007/s10620-007-0176-8.
[21]	Geboers DG, de Beer FM, Tuip-de Boer AM, et al. Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients[J]. Intensive Care Med, 2015, 41(7): 1281-90. Dig: 10.1007/s00134-015-3924-9. doi: 10.1007/s00134-015-3924-9
[22]	Chen C, Shi L, Li Y, et al. Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia[J]. Cell Biol Toxicol, 2016, 32(3):169-184. DOI: 10.1007/s10565-016-9322-4.
[23]	Chiari MM, Bagnoli R, De Luca PD, et al. Influence of acute inflammation on iron and nutritional status indexes in older inpatients[J]. J Am Geriatr Soc, 1995, 43(7):767-771. doi: 10.1111/jgs.1995.43.issue-7
[24]	Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device[J]. Perfusion, 2005, 20(2): 83-90. doi: 10.1191/0267659105pf793oa
[25]	Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis[J]. Antioxid Redox Signal, 2008, 10(11): 1923-1940. DOI: 10.1089/ars.2008.2142.
[26]	Ujszaszi A, Molnar MZ, Czira ME, et al. Renal function is independently associated with red cell distribution width in kidney transplant recipients: a potential new auxiliary parameter for the clinical evaluation of patients with chronic kidney disease[J]. Br J Haematol, 2013, 161(5): 715-725. DOI: 10.1111/bjh.12315.
[27]	Mucsi I, Ujszaszi A, Czira ME, et al. Red cell distribution width is associated with mortality in kidney transplant recipients[J]. Int Urol Nephrol, 2014, 46(3): 641-651. doi: 10.1007/s11255-013-0530-z

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1) / Tables(3)

Get Citation

PDF

XML

Article Metrics

Article views (115) PDF downloads(4)

Correlation analysis between red cell volume distribution width and the mortality rate in ARDS patients after renal transplantation

doi: 10.3969/j.issn.1674-7445.2017.04.005

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Correlation analysis between red cell volume distribution width and the mortality rate in ARDS patients after renal transplantation

doi: 10.3969/j.issn.1674-7445.2017.04.005

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content