Changes of erythrocytes surface molecule  CD35, CD58 and CD59 expression  in recipients infected with cytomegalovirus after renal transplantation Kong

Kong Xiangrui; Xiao Li; Chen Wen; Fan Wenmei; Bai Jian; Gao Yu; Ma Xihui; Bi Lili; Shi Bingyi

doi:10.3969/j.issn.1674-7445.2016.06.012

Volume 7 Issue 6

Nov. 2016

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Kong Xiangrui, Xiao Li, Chen Wen, et al. Changes of erythrocytes surface molecule CD35, CD58 and CD59 expression in recipients infected with cytomegalovirus after renal transplantation Kong[J]. ORGAN TRANSPLANTATION, 2016, 7(6): 473-478. doi: 10.3969/j.issn.1674-7445.2016.06.012

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Changes of erythrocytes surface molecule CD35, CD58 and CD59 expression in recipients infected with cytomegalovirus after renal transplantation Kong

doi: 10.3969/j.issn.1674-7445.2016.06.012

Organ Transplant Institute of People's Liberation Army, the 309^th Hospital of People's Liberation Army, Beijing Key Laboratory of Immunology Regulatory and Organ Transplantation, Beijing 100091, China

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Corresponding author: Shi Bingyi. E-mail:shibingyi@medmail.com.cn.
Received Date: 2016-07-10
Available Online: 2021-03-19
Publish Date: 2016-11-15

Abstract

Abstract

Objective To investigate the change rules and its significance of erythrocytes surface molecule CD35, CD58 and CD59 expression in recipients infected with cytomegalovirus (CMV) after renal transplantation. Methods Eighty-two recipients undergoing allogeneic renal transplantation were selected and divided into the negative (n=21) and positive CMV groups (n=61) based on the qualitative detection of CMV-pp65 antigen in peripheral blood. According to the results of CMV-pp65 (+) leucocyte count, all 61 patients in positive CMV group were further divided into low (n=55) and high active infection subgroups (n=6). Healthy adults were recruited into the normal control group (n=30). The expression levels of CMV-pp65 antigen, erythrocytes surface molecule CD35, CD58 and CD59 were measured by flow cytometry. Results Compared with normal control group, the expression levels of erythrocytes surface molecule CD35, CD58 and CD59 in the positive CMV group were significantly down-regulated, and the CD35 and CD59 expression in the negative CMV group were considerably down-regulated (all P＜0.05). Compared with negative CMV group, the expression levels of CD58 and CD59 in the positive CMV group were significantly down-regulated (both P＜0.05). The expression levels of CD35 and CD59 in the high active infection subgroup were significantly lower than those in the low active infection subgroup (both P＜0.05). Conclusions The more severe active CMV infection after renal transplantation, the lower expression of erythrocytes surface molecule CD35, CD58 and CD59, hinting that red cell immune dysfunction is probably involved with active CMV infection.
- Renal transplantation,
- Cytomegalovirus,
- Active infection,
- Erythrocytes,
- CD35,
- CD58,
- CD59

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Changes of erythrocytes surface molecule CD35, CD58 and CD59 expression in recipients infected with cytomegalovirus after renal transplantation Kong

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