Volume 7 Issue 6
Nov.  2016
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Xiong Liang, Li Lijuan, An Yuling, et al. Analysis on cause, prevention and treatment of intra-abdominal hemorrhage after liver transplantation: a report of 82 cases[J]. ORGAN TRANSPLANTATION, 2016, 7(6): 463-466. doi: 10.3969/j.issn.1674-7445.2016.06.010
Citation: Xiong Liang, Li Lijuan, An Yuling, et al. Analysis on cause, prevention and treatment of intra-abdominal hemorrhage after liver transplantation: a report of 82 cases[J]. ORGAN TRANSPLANTATION, 2016, 7(6): 463-466. doi: 10.3969/j.issn.1674-7445.2016.06.010
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Analysis on cause, prevention and treatment of intra-abdominal hemorrhage after liver transplantation: a report of 82 cases

doi: 10.3969/j.issn.1674-7445.2016.06.010

  • Intensive Care Unit of Organ Transplantation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

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  • Corresponding author: Yi Huimin. E-mail:ylhmin@hotmail.com.
  • Received Date: 2016-09-06
    Available Online: 2021-03-19
  • Publish Date: 2016-11-15
    Abstract
  •   Objective   To investigate the cause, prevention and treatment of intra-abdominal hemorrhage after liver transplantation.   Methods   Clinical data of 82 patients undergoing liver transplantation were retrospectively analyzed. All participants were divided into the intra-abdominal hemorrhage (n=12) and control groups (n=70). Preoperative parameters including age, model for end-stage liver disease (MELD) score, prothrombin time (PT), prothrombin time international normalized ratio (PT-INR), fibrinogen (FIB), activated partial thromboplastin time (APTT), platelet (Plt) were statistically compared between two groups. Intraoperative hemorrhage volume, cold ischemia time of donor liver, anhepatic phase time and operation time were also compared between two groups. Postoperatively, the mortality rate was compared between two groups.   Results   Among 82 patients, 12 (15%) presented with intra-abdominal hemorrhage and required twice surgical hemostasis. In the intra-abdominal hemorrhage group, 4 cases (33%) died, and 8 (11%) died in the control group. No statistical significance was documented between two groups (P>0.05). Age, MELD score, PT-INR, FIB, APTT and PLT did not significantly differ between two groups (all P>0.05). Compared with patients in the control group, those in the intra-abdominal hemorrhage group yielded significantly more blood loss intraoperatively, longer operation time and longer cold ischemia time of donor liver (all P＜0.05). Anhepatic phase time did not significantly differ between two groups (P>0.05).   Conclusions   After liver transplantation, intra-abdominal hemorrhage is associated with longer cold ischemia time of donor liver, more intraoperative blood loss and longer operation time. In order to decrease the incidence of postoperative intra-abdominal hemorrhage, coagulation function should be completely corrected prior to surgery and the surgical skills should also be enhanced.

     

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