Volume 7 Issue 6
Nov.  2016
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2016  >  7(6): 438-443
Du Guosheng, Zhou Lin, Zheng Yonggen, et al. Experience of clinical treatment on patients on cirrhosis or liver cancer complicated with psoriasis after liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(6): 438-443. doi: 10.3969/j.issn.1674-7445.2016.06.005
Citation: Du Guosheng, Zhou Lin, Zheng Yonggen, et al. Experience of clinical treatment on patients on cirrhosis or liver cancer complicated with psoriasis after liver transplantation[J]. ORGAN TRANSPLANTATION, 2016, 7(6): 438-443. doi: 10.3969/j.issn.1674-7445.2016.06.005
shu

Experience of clinical treatment on patients on cirrhosis or liver cancer complicated with psoriasis after liver transplantation

doi: 10.3969/j.issn.1674-7445.2016.06.005

  • Department of Hepatobiliary Surgery, Organ Transplant Institute of People's Liberation Army, the 309th Hospital of People's Liberation Army, Beijing 100091, China

More Information
  • Corresponding author: 英文姓名. E-mail:duguosheng@medmail.com.cn.
  • Received Date: 2016-07-30
    Available Online: 2021-03-19
  • Publish Date: 2016-11-15
    Abstract
  •   Objective   To summarize the clinical experience of immunosuppressive therapy for recipients suffering from psoriasis after liver transplantation.   Methods   Five patients diagnosed with cirrhosis or hepatocellular carcinoma(HCC) complicated with psoriasis after liver transplantation were recruited in this clinical trial. All participants were positive for serum biomarkers of hepatitis B virus (HBV). Induction therapy was adopted before surgery. Immunosuppressive regime of tacrolimus (FK506), mycophenolate mofetil (MMF) and adrenal cortical hormone (hormone)was implemented early after surgery. The hormone use was terminated within 1 week. Three cases of cirrhosis complicated with HCC due to chronic HBV infection were gradually switched to sirolimus substitution treatment within 1 month after liver transplantation. Two patients with cirrhosis were administered with FK506 with or without MMF following liver transplantation. All patients received anti-HBV therapy. Baseline data, changes in psoriasis area and severity index (PASI) score and adjustment of postoperative immunosuppressive agents were analyzed.   Results   Five patients undergoing transplantation were followed up until the submission date with a mean duration of (8.3±1.5) years and survived. Compared with preoperative values, PASI score was significantly reduced at postoperative 6 months (P＜0.05). Two patients with cirrhosis had recurrent psoriasis at 2 years after liver transplantation. PASI score was significantly increased and steadily declined after sirolimus substitution therapy. These patients remained physically stable and did not progress at postoperative 3 years. Three patients suffering from cirrhosis complicated with HCC presented with no recurrence of psoriasis postoperatively.   Conclusions   Sirolimus-based immunosuppressive therapy can effectively control the progression of psoriasis in liver transplantation recipients. Anti-HBV treatment should be simultaneously implemented for HBV positive patients.

     

    • FullText(HTML)
  • loading
    • References(21)
  • [1]
    "Diani M, Altomare G, Reali E. T cell responses in psoriasis and psoriatic arthritis[J]. Autoimmun Rev, 2015, 14(4):286-292. doi: 10.1016/j.autrev.2014.11.012
    [2]
    Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis[J]. Annu Rev Immunol, 2014,32: 227-255. doi: 10.1146/annurev-immunol-032713-120225
    [3]
    Madankumar R, Teperman LW, Stein JA. Use of etanercept for psoriasis in a liver transplant recipient[J]. JAAD Case Rep, 2015,1(6):S36-S37. doi: 10.1016/j.jdcr.2015.09.012
    [4]
    中华医学会皮肤性病学分会银屑病学组. 中国银屑病治疗指南(2008版)[J]. 中国实用乡村医生杂志，2014,21(2)：2-4.

    Psoriasis Study Group of Skin Venereal Diseases Branch of Chinese Medical Association. Guidelines of psoriasis treatment in China(2008)[J]. Chin Pract J Rural Doct，2014,21(2)：2-4.
    [5]
    Kolios AG, Yawalkar N, Anliker M, et al. Swiss S1 guidelines on the systemic treatment of psoriasis vulgaris[J]. Dermatology,2016, 232(4):385-406. doi: 10.1159/000445681
    [6]
    Yang ZS, Lin NN, Li L, et al. The Effect of TNF inhibitors on cardiovascular events in psoriasis and psoriatic arthritis: an updated Meta-analysis[J]. Clin Rev Allergy Immunol, 2016, 51(2):240-247. doi: 10.1007/s12016-016-8560-9
    [7]
    Foroncewicz B, Mucha K, Lerut J, et al. Cyclosporine is superior to tacrolimus in liver transplant recipients with recurrent psoriasis[J]. Ann Transplant, 2014, 19: 427-433. doi: 10.12659/AOT.890754
    [8]
    Reich K, Burden AD, Eaton JN, et al. Efficacy of biologics in the treatment of moderate to severe psoriasis: a network meta-analysis of randomized controlled trials[J]. Br J Dermatol,2012,166(1):179-188. doi: 10.1111/j.1365-2133.2011.10583.x
    [9]
    Collazo MH, González JR, Torres EA. Etanercept therapy for psoriasis in a patient with concomitant hepatitis C and liver transplant[J]. P R Health Sci J, 2008,27(4):346-347. http://cn.bing.com/academic/profile?id=1514365248&encoded=0&v=paper_preview&mkt=zh-cn
    [10]
    Hoover WD. Etanercept therapy for severe plaque psoriasis in a patient who underwent a liver transplant[J]. Cutis, 2007,80(3):211-214. http://cn.bing.com/academic/profile?id=2471107116&encoded=0&v=paper_preview&mkt=zh-cn
    [11]
    夏念信,邱宝安,黄东东,等. 他克莫司治疗肝移植伴银屑病一例[J/CD].中华临床医师杂志(电子版)，2013，7(4) : 1825-1826．

    Xia NX, Qiu BA, Huang DD, et al. Therapy of tacrolimus on liver transplantation with psoriasis for one case[J/CD]. Chin J Clin (Electr Edit)，2013，7(4): 1825-1826．
    [12]
    Lythgoe M, Abraham S. Tacrolimus: an effective treatment in refractory psoriatic arthritis following biologic failure[J]. Clin Exp Rheumatol, 2016,34(1 Suppl 95):S12-S13. http://cn.bing.com/academic/profile?id=961857829&encoded=0&v=paper_preview&mkt=zh-cn
    [13]
    Wei KC, Lai PC. Combination of everolimus and tacrolimus: a potentially effective regimen for recalcitrant psoriasis[J]. Dermatol Ther,2015,28(1):25-27. doi: 10.1111/dth.2015.28.issue-1
    [14]
    Tirado-Sánchez A, Ponce-Olivera RM. Preliminary study of the efficacy and tolerability of combination therapy with calcipotriene ointment 0.005% and tacrolimus ointment 0.1% in the treatment of stable plaque psoriasis[J]. Cutis,2012,90(3): 140-144． http://cn.bing.com/academic/profile?id=192649796&encoded=0&v=paper_preview&mkt=zh-cn
    [15]
    Laino L, DiCarlo A. Palmoplantar pustular psoriasis: clinical and video thermographic evaluation before and after topical tacrolimus treatment[J]. Arch Dermatol,2011,147(6): 760. doi: 10.1001/archdermatol.2011.120
    [16]
    Foroncewicz B, Mucha K, Paczek L, et al. Anti-CD25 and tacrolimus therapy may not prevent early primary biliary cirrhosis recurrence after liver transplantation: two case reports[J]. Transplant Proc, 2003, 35(6): 2310-2312. doi: 10.1016/S0041-1345(03)00835-2
    [17]
    Abu-Elmagd K, Van Thiel D, Jegasothy BV, et al. FK506: a new therapeutic agent for severe recalcitrant psoriasis[J]. Transplant Proc,1991,23(6):3322-3324. http://cn.bing.com/academic/profile?id=2007179975&encoded=0&v=paper_preview&mkt=zh-cn
    [18]
    Gilbert SC, Klintmalm G, Menter A, et al. Methotrexate-induced cirrhosis requiring liver transplantation in three patients with psoriasis. a word of caution in light of the expanding use of this ‘steroid-sparing’ agent[J]. Arch Intern Med, 1990,150(4):889-891. doi: 10.1001/archinte.1990.00390160129025
    [19]
    Steglich RB, Meneghello LP, Carvalho AV, et al. The use of ustekinumab in a patient with severe psoriasis and positive HBV serology[J]. An Bras Dermatol, 2014,89(4):652-654. doi: 10.1590/abd1806-4841.20143013
    [20]
    Cho YT, Chen CH, Chiu HY, et al. Use of anti-tumor necrosis factor-α therapy in hepatitis B virus carriers with psoriasis or psoriatic arthritis: a case series in Taiwan[J]. Dermatol, 2012,39(3):269-273. doi: 10.1111/j.1346-8138.2011.01434.x
    [21]
    Cassano N, Mastrandrea V, Principi M, et al. Anti-tumor necrosis factor treatment in occult hepatitis B virus infection: a retrospective analysis of 62 patients with psoriatic disease[J]. J Biol Regul Homeost Agents, 2011,25(2):285-289. http://cn.bing.com/academic/profile?id=1415223797&encoded=0&v=paper_preview&mkt=zh-cn
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(3)  / Tables(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (229) PDF downloads(11) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return