肾移植新兴生物标志物之研究进展

郑瑾; 薛武军

doi:10.3969/j.issn.1674-7445.2023.02.003

肾移植新兴生物标志物之研究进展

doi: 10.3969/j.issn.1674-7445.2023.02.003

郑瑾,
薛武军^,

710061 西安，西安交通大学第一附属医院肾脏病医院肾移植科

基金项目:

国家自然科学基金 82170768

详细信息

作者简介:

通讯作者:
薛武军，博士，主任医师，教授，研究方向为肾移植，Email：xwujun126@xjtu.edu.cn

中图分类号: R617, R692
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- 被引次数: 0
出版历程
- 收稿日期: 2022-10-16
- 网络出版日期: 2023-03-15
- 刊出日期: 2023-03-15

Research progress on emerging biomarkers in kidney transplantation

Zheng Jin,
Xue Wujun^,

Department of Kidney Transplantation, Kidney Disease Hospital, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

More Information

Corresponding author: Xue Wujun, Email: xwujun126@xjtu.edu.cn

摘要

摘要: 宿主对移植器官的免疫反应复杂多样，能否利用生物标志物解释移植物免疫反应的复杂性和疾病损伤的程度至关重要。传统的生物标志物如估算肾小球滤过率、免疫抑制药血药浓度等在精准识别移植肾免疫性和非免疫性损伤方面缺乏灵敏度和特异度。移植肾活组织检查虽然是目前诊断术后并发症的“金标准”，但是存在有创和费用昂贵等缺点。新兴生物标志物在移植肾亚临床损伤的无创诊断、治疗反应的预测和免疫抑制方案的个体化调整方面具有潜在优势。本文综述了肾移植领域近年来已经进入和有希望进入临床应用的新兴生物标志物，包括血液、尿液和组织生物标志物，并分析了其应用范围和效果，以期能促进有前景的新兴生物标志物更好地、合理地应用于临床。
- 肾移植 /
- 生物标志物 /
- 无创监测 /
- 排斥反应 /
- 估算肾小球滤过率 /
- 供者特异性抗体 /
- 供者来源性细胞游离DNA /
- 细胞外囊泡 /
- 单核苷酸多态性（SNP）
Abstract: The hosts could show complex and diverse immune responses to the allografts. Whether biomarkers can be employed to explain the complexity of graft immune responses and the degree of disease damage are of significance. Conventional biomarkers, such as estimated glomerular filtration rate and blood concenrtation of immunosuppressant, lack of sensitivity and specificity in accurately identifying between immune and non-immune renal allograft injuries. Although renal biopsy is the "gold standard" for the diagnosis of postoperative complications, it still has disadvantages, such as invasiveness and high price, etc. Emerging biomarkers have potential advantages in the non-invasive diagnosis of subclinical injury of renal allograft, prediction of treatment response and individualized adjustment of immunosuppressive regimen. In this article, emerging biomarkers including blood, urine and tissue biomarkers that have been applied and are expected to be applied in clinical practice in the field of kidney transplantation were reviewed, and the range of application and effect of these biomarkers were evaluated, aiming to promote appropriate and rational application of these promising emerging biomarkers in clinical practice.
- Kidney transplantation /
- Biomarker /
- Non-invasive monitoring /
- Rejection /
- Estimated glomerular filtration rate /
- Donor specific antibody /
- Donor-derived cell-free DNA /
- Extracellular vesicle /
- Single nucleotide polymorphism(SNP)

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参考文献(44)

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