DAMP与NET在器官缺血-再灌注损伤中作用新进展

邹志锐; 满江位; 杨立

doi:10.3969/j.issn.1674-7445.2021.06.018

DAMP与NET在器官缺血-再灌注损伤中作用新进展

doi: 10.3969/j.issn.1674-7445.2021.06.018

730000 兰州大学第二医院泌尿科

基金项目:

甘肃省自然科学基金 17JR5RA237

兰州大学第二医院“萃英科技创新”计划 CY2018-BJ02

详细信息

作者简介:
邹志锐，男，1996年生，硕士研究生，研究方向为肾脏缺血-再灌注损伤，Email: zouzhirui1996ts@163.com

通讯作者:
杨立，男，1971年生，博士，主任医师，研究方向为肾移植，Email: ery_yangli@lzu.edu.cn

中图分类号: R617, R392.12
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出版历程
- 收稿日期: 2021-07-06
- 刊出日期: 2021-11-15

Recent progress on the roles of DAMP and NET in organ ischemia-reperfusion injury

Department of Urology, Lanzhou University Second Hospital, Lanzhou 730000, China

More Information

Corresponding author: Yang Li, Email: ery_yangli@lzu.edu.cn

摘要

摘要: 缺血-再灌注损伤（IRI）是一种常见的病理生理现象，继发于器官移植、急性肾损伤、心肌梗死等众多病理过程中，显著增加了疾病严重程度与患者病死率。无菌性炎症是IRI的重要机制之一。细胞损伤相关分子模式（DAMP）是介导无菌性炎症的重要物质，其释放到胞外，通过与模式识别受体（PRR）结合，可有效激活免疫系统，启动并维持炎症反应。中性粒细胞胞外诱捕网（NET）是在炎症反应过程中由中性粒细胞释放的以DNA为骨架，含有组蛋白与众多颗粒蛋白的网状结构。近些年研究发现，DAMP与NET可通过无菌性炎症加剧IRI。本文回顾了DAMP、NET及其相互关系在IRI中的相关研究，对于理解IRI的病理生理学机制以及研究相应的防治策略有着重要的意义。
- 缺血-再灌注损伤（IRI） /
- 损伤相关分子模式（DAMP） /
- 中性粒细胞胞外诱捕网（NET） /
- 无菌性炎症 /
- Toll样受体（TLR） /
- 线粒体DNA（mtDNA） /
- 胞外冷诱导RNA结合蛋白（eCIRP） /
- 高迁移率族蛋白1（HMGB1）
Abstract: Ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon, secondary to multiple pathological processes, such as organ transplantation, acute kidney injury and myocardial infarction. IRI may significantly aggravate the severity of diseases and increase the fatality of patients. Aseptic inflammation is one of the critical mechanisms of IRI. Damage-associated molecular pattern (DAMP) is a pivotal substance, which mediates aseptic inflammation. After released into extracellular space, it could effectively activate the immune system, and initiate and maintain the inflammatory responses by binding with pattern recognition receptor (PRR). Neutrophil extracellular trap (NET) is a DNA-based network structure released by neutrophils during the process of inflammatory responses, which contains histones and multiple granular proteins. Recent studies have demonstrated that DAMP and NET may aggravate IRI via aseptic inflammation. In this article, relevant studies of DAMP, NET and their relationship in IRI were reviewed, which was of great significance for understanding the pathophysiological mechanism of IRI and studying the corresponding prevention and treatment strategies.

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