2020年ATC肾移植相关基础与转化医学研究国际前沿热点

何健楠; 孙启全

doi:10.3969/j.issn.1674-7445.2021.01.004

2020年ATC肾移植相关基础与转化医学研究国际前沿热点

doi: 10.3969/j.issn.1674-7445.2021.01.004

何健楠,
孙启全^,

510630 广州，中山大学附属第三医院肾移植科

基金项目:

国家自然科学基金 81970650

国家自然科学基金 81770753

国家自然科学基金 81800662

详细信息

作者简介:
何健楠，男，1993年生，八年制博士研究生，研究方向为排斥反应和免疫耐受，Email：hejn@mail2.sysu.edu.cn

通讯作者:
孙启全，男，1973年生，博士，教授，主任医师，研究方向为肾移植相关疾病，Email：sunqiq@mail.sysu.edu.cn

中图分类号: R617, R392.4
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- 被引次数: 0
出版历程
- 收稿日期: 2020-10-27
- 网络出版日期: 2021-01-19
- 刊出日期: 2021-01-19

International frontier hotspots of basic and translational medicine research related to renal transplantation at the 2020 ATC

He Jiannan,
Sun Qiquan^,

Department of Renal Transplantation, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China

More Information

Corresponding author: Sun Qiquan, Email: sunqiq@mail.sysu.edu.cn

摘要

摘要: 美国移植年会（ATC）是移植学领域一年一度的国际学术盛会，其报道的内容囊括了世界各地学者在移植领域的最新成果，也引领了移植相关研究的前沿方向。本文就2020年ATC中与肾移植相关的基础与转化医学研究国际前沿热点进行概述，包括免疫记忆性细胞功能和免疫记忆机制的新发现，排斥反应和免疫耐受机制的最新探索，异种移植的研究现状，抗体介导的排斥反应（AMR）的潜在解决策略，纳米医学、单细胞RNA测序等新型技术在肾移植中的应用前景等。
- 美国移植年会（ATC） /
- 肾移植 /
- 免疫记忆 /
- 异种移植 /
- 抗体介导的排斥反应（AMR） /
- 免疫耐受 /
- 纳米医学 /
- 单细胞RNA测序
Abstract: The American Transplant Congress (ATC) is an annual international academic conference in the field of transplantation, which includes the latest achievements of scholars around the world in transplantation, and also leads the frontier direction of transplantation research. In this paper, the international forefront hotspots in basic and translational medicine research associated with renal transplantation in 2020 ATC were summarized, including the new discoveries of memory cell function and immune memory mechanism, the latest discovery in the mechanism of rejection and immune tolerance, the current research status of xenotransplantation, the potential solutions of antibody-mediated rejection (AMR), and the application of nanomedicine and single-cell RNA sequencing in renal transplantation, etc.
- American Transplant Congress (ATC) /
- Renal transplantation /
- Immune memory /
- Xenotransplantation /
- Antibody-mediated rejection (AMR) /
- Immune tolerance /
- Nanomedicine /
- Single-cell RNA sequencing

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参考文献(28)

[1]	GEBHARDT T, WAKIM LM, EIDSMO L, et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus[J]. Nat Immunol, 2009, 10(5):524-530. DOI: 10.1038/ni.1718.
[2]	WAKIM LM, WOODWARD-DAVIS A, BEVAN MJ. Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence[J]. Proc Natl Acad Sci U S A, 2010, 107(42):17872-17879. DOI: 10.1073/pnas.1010201107.
[3]	ABOU-DAYA K, ZHAO D, TIEU R, et al. Tissue resident memory T cells in mouse renal transplantation [J]. Am J Transplant, 2020, 20 (Suppl 3):13.
[4]	KRUPNICK AS, LIN X, LI W, et al. Central memory CD8⁺ T lymphocytes mediate lung allograft acceptance[J]. J Clin Invest, 2014, 124(3):1130-1143. DOI: 10.1172/JCI71359.
[5]	LI S, XIE Q, ZENG Y, et al. A naturally occurring CD8(+)CD122(+) T-cell subset as a memory-like Treg family[J]. Cell Mol Immunol, 2014, 11(4):326-331. DOI: 10.1038/cmi.2014.25.
[6]	MORRIS AB, PINELLI DF, LIU D, et al. Memory T cell-mediated rejection is mitigated by FcγRIIB expression on CD8⁺ T cells[J]. Am J Transplant, 2020, 20(8):2206-2215. DOI: 10.1111/ajt.15837.
[7]	LIU W, XIAO X, DEMIRCI G, et al. Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms[J]. J Immunol, 2012, 188(6):2703-2711. DOI: 10.4049/jimmunol.1102997.
[8]	SUN JC, BEILKE JN, LANIER LL. Adaptive immune features of natural killer cells[J]. Nature, 2009, 457(7229):557-561. DOI: 10.1038/nature07665.
[9]	DAI H, LAN P, ZHAO D, et al. PIRs mediate innate myeloid cell memory to nonself MHC molecules[J]. Science, 2020, 368(6495):1122-1127. DOI: 10.1126/science.aax4040.
[10]	FORD ML, ADAMS AB, PEARSON TC. Targeting co-stimulatory pathways: transplantation and autoimmunity[J]. Nat Rev Nephrol, 2014, 10(1):14-24. DOI: 10.1038/nrneph.2013.183.
[11]	KINNEAR G, JONES ND, WOOD KJ. Costimulation blockade: current perspectives and implications for therapy[J]. Transplantation, 2013, 95(4):527-535. DOI: 10.1097/TP.0b013e31826d4672.
[12]	LIU D, FORD ML. CD11b is a novel alternate receptor for CD154 during alloimmunity[J]. Am J Transplant, 2020, 20(8):2216-2225. DOI: 10.1111/ajt.15835.
[13]	AHRENS K, O JM, SOMMER W, et al. Cardiac allograft tolerance can be achieved in non-human primates via transient mixed hematopoietic chimerism and erythropoietin administration [J]. Am J Transplant, 2020, 20 (Suppl 3):1025.
[14]	BUTLER JR, TECTOR AJ. CRISPR genome-editing: a medical revolution[J]. J Thorac Cardiovasc Surg, 2017, 153(2):488-491. DOI: 10.1016/j.jtcvs.2016.08.067.
[15]	COOPER DKC, GASTON R, ECKHOFF D, et al. Xenotransplantation-the current status and prospects[J]. Br Med Bull, 2018, 125(1):5-14. DOI: 10.1093/bmb/ldx043.
[16]	MA DH, SASAKI H, HIROSE T, et al. Successful long-term TMA- and rejection- free survival of a kidney xenograft with triple xenoantigen knockout plus insertion of multiple human transgenes[J]. Am J Transplant, 2020, 20(Suppl 3):752.
[17]	HIGGINBOTHAM L, MATHEWS D, BREEDEN CA, et al. Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model[J]. Xenotransplantation, 2015, 22(3):221-230. DOI: 10.1111/xen.12166.
[18]	CHONG AS, ROTHSTEIN DM, SAFA K, et al. Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection[J]. Am J Transplant, 2019, 19(8):2155-2163. DOI: 10.1111/ajt.15323.
[19]	BERGER M, LEFAUCHEUR C, JORDAN SC. Update on C1 esterase inhibitor in human solid organ transplantation[J]. Transplantation, 2019, 103(9):1763-1775. DOI: 10.1097/TP.0000000000002717.
[20]	BLANTON C, REYES J, EERHART M, et al. Donor intervention and recipient treatment with recombinant human C1 inhibitor prevents delayed graft function in a non-human primate model of kidney transplantation[J]. Am J Transplant, 2020, 20(Suppl 3):256.
[21]	HAJEBI S, RABIEE N, BAGHERZADEH M, et al. Stimulus-responsive polymeric nanogels as smart drug delivery systems[J]. Acta Biomater, 2019, 92:1-18. DOI: 10.1016/j.actbio.2019.05.018.
[22]	HASHIMOTO Y, MUKAI SA, SASAKI Y, et al. Nanogel tectonics for tissue engineering: protein delivery systems with nanogel chaperones[J]. Adv Healthc Mater, 2018, 7(23):e1800729. DOI: 10.1002/adhm.201800729.
[23]	ESKANDARI SK, ALHADDAD JB, SULKAJ I, et al. Regulatory T cells engineered with TCR-signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter[J] Am J Transplant, 2020, 20(suppl 3):331.
[24]	TINEL C, LAMARTHÉE B, VON TOKARSKI F, et al. A monocyte-derived microRNA signature for antibody-mediated rejection in kidney transplantation[J]. Am J Transplant, 2020, 20(Suppl 3):309.
[25]	GAO S. Data analysis in single-cell transcriptome sequencing[J]. Methods Mol Biol, 2018, 1754:311-326. DOI: 10.1007/978-1-4939-7717-8_18.
[26]	WU H, HUMPHREYS BD. The promise of single-cell RNA sequencing for kidney disease investigation[J]. Kidney Int, 2017, 92(6):1334-1342. DOI: 10.1016/j.kint. 2017.06.033.
[27]	MALONE AF, HUMPHREYS BD. Single-cell transcriptomics and solid organ transplantation[J]. Transplantation, 2019, 103(9):1776-1782. DOI: 10.1097/TP.0000000000002725.
[28]	NAIK AS, MENON R, OTTO E, et al. Single cell RNA sequencing of normal kidney allograft surveillance biopsies show evidence of dynamic glomerular endothelial cell activation [J]. Am J Transplant, 2020, 20 (Suppl 3):13.