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声触诊组织定量技术诊断不同时期移植肾急性排斥反应的临床价值

樊韵玲 杨萍 杨橙 季正标 何婉媛 王文平

樊韵玲, 杨萍, 杨橙, 等. 声触诊组织定量技术诊断不同时期移植肾急性排斥反应的临床价值[J]. 器官移植, 2020, 11(5): 589-593. doi: 10.3969/j.issn.1674-7445.2020.05.010
引用本文: 樊韵玲, 杨萍, 杨橙, 等. 声触诊组织定量技术诊断不同时期移植肾急性排斥反应的临床价值[J]. 器官移植, 2020, 11(5): 589-593. doi: 10.3969/j.issn.1674-7445.2020.05.010
Fan Yunling, Yang Ping, Yang Cheng, et al. Clinical value of virtual touch tissue quantification technique in diagnosing acute rejection of transplant kidney at different stages[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 589-593. doi: 10.3969/j.issn.1674-7445.2020.05.010
Citation: Fan Yunling, Yang Ping, Yang Cheng, et al. Clinical value of virtual touch tissue quantification technique in diagnosing acute rejection of transplant kidney at different stages[J]. ORGAN TRANSPLANTATION, 2020, 11(5): 589-593. doi: 10.3969/j.issn.1674-7445.2020.05.010

声触诊组织定量技术诊断不同时期移植肾急性排斥反应的临床价值

doi: 10.3969/j.issn.1674-7445.2020.05.010
基金项目: 

上海市科学技术委员会医学引导类项目 15411964900

上海市临床重点专科项目 shslczdzk03501

中国器官移植发展基金会“菁英计划” 2019JYJH05

详细信息
    作者简介:

    樊韵玲, 女, 1993年生, 硕士, 住院医师, 研究方向为腹部超声, Email:yunlingfan201@163.com

    通讯作者:

    何婉媛, 女, 1968年生, 硕士, 主任医师, 研究方向为移植肾的超声诊断与研究, Email:he.wanyuan@zs-hospital.sh.cn

  • 中图分类号: R617, R445.1

Clinical value of virtual touch tissue quantification technique in diagnosing acute rejection of transplant kidney at different stages

More Information
  • 摘要:   目的  探讨声触诊组织定量(VTQ)技术在诊断不同时期移植肾急性排斥反应中的临床价值。  方法  回顾性分析170例肾移植受者的临床资料。根据受者行VTQ检查的时间以及肾移植术后急性排斥反应的发生情况, 将肾移植术后4周内和术后4周后的受者分为肾功能正常组(41例和51例)、急性排斥反应组(22例和56例)。比较肾移植术后不同时期肾功能正常组和急性排斥反应组的临床超声参数情况; 分析超声参数在肾移植术后不同时期急性排斥反应中的诊断价值。  结果  肾移植术后4周内, 急性排斥反应组的阻力指数(RI)和剪切波速度(SWV)均明显高于肾功能正常组(均为P < 0.001);术后4周后, 急性排斥反应组SWV明显高于肾功能正常组(P < 0.001)。术后4周内, RI、SWV诊断急性排斥反应的曲线下面积(AUC)分别为0.729、0.803;术后4周后, RI、SWV诊断急性排斥反应的AUC分别为0.478、0.794, SWV的诊断价值高于RI(P < 0.05)。术后4周内SWV诊断急性排斥反应的截断值高于术后4周后。  结论  VTQ技术能有效辅助诊断不同时期移植肾急性排斥反应。

     

  • 表  1  肾移植术后不同时期肾功能正常组和急性排斥反应组的超声参数

    Table  1.   Ultrasound parameters of normal renal function group and acute rejection group at different stages after renal transplantation(x±s)

    参数 术后4周内 P 术后4周后 P
    肾功能正常组(n=41) 急性排斥反应组(n=22) 肾功能正常组(n=51) 急性排斥反应组(n=56)
    PSV(m/s) 0.49±0.15 0.47±0.19 0.150 0.46±0.16 0.41±0.19 0.176
    RI 0.62±0.08 0.78±0.18 < 0.001 0.62±0.09 0.61±0.08 0.717
    SWV(m/s) 2.55±0.41 2.99±0.23 < 0.001 2.39±0.34 2.75±0.34 < 0.001
    下载: 导出CSV

    表  2  肾移植术后不同时期超声参数诊断急性排斥反应的ROC曲线分析

    Table  2.   ROC curve analysis of ultrasound parameters in diagnosis of acute rejection at different stages after renal transplantation

    参数 AUC 截断值 灵敏度 特异度 P
    RI
      术后4周内 0.729 0.800 0.455 1.000 0.003
      术后4周后 0.478 0.560 0.821 0.275 0.697
    SWV(m/s)
      术后4周内 0.803 2.620 1.000 0.634 0.000
      术后4周后 0.794 2.430 0.875 0.686 0.000
    下载: 导出CSV
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出版历程
  • 收稿日期:  2020-05-27
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2020-09-15

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