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体外光化学疗法抑制器官移植免疫排斥反应的作用机制

魏玉香 石炳毅

魏玉香, 石炳毅. 体外光化学疗法抑制器官移植免疫排斥反应的作用机制[J]. 器官移植, 2019, 10(5): 608-611. doi: 10.3969/j.issn.1674-7445.2019.05.024
引用本文: 魏玉香, 石炳毅. 体外光化学疗法抑制器官移植免疫排斥反应的作用机制[J]. 器官移植, 2019, 10(5): 608-611. doi: 10.3969/j.issn.1674-7445.2019.05.024
Wei Yuxiaug, Shi Bingyi. Mechanism of extracorporeal photochemotherapy in inhibiting immune rejection in organ transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(5): 608-611. doi: 10.3969/j.issn.1674-7445.2019.05.024
Citation: Wei Yuxiaug, Shi Bingyi. Mechanism of extracorporeal photochemotherapy in inhibiting immune rejection in organ transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(5): 608-611. doi: 10.3969/j.issn.1674-7445.2019.05.024

体外光化学疗法抑制器官移植免疫排斥反应的作用机制

doi: 10.3969/j.issn.1674-7445.2019.05.024
基金项目: 

国家自然科学基金 81370578

详细信息
    作者简介:

    魏玉香,女,1968年生,博士,副主任技师,研究方向为移植免疫,Email:bjwyx1970@163.com

    通讯作者:

    石炳毅,Email:shibingyi666@126.com

  • 中图分类号: R617, R392.4

Mechanism of extracorporeal photochemotherapy in inhibiting immune rejection in organ transplantation

  • 摘要: 体外光化学疗法(ECP)是以分离外周血单个核细胞(PBMC)技术为基础,通过加入光敏剂和紫外线处理,再回输入患者体内的一种免疫治疗方法。ECP首先应用于治疗皮肤T细胞淋巴瘤,并取得成功。后来又被先后应用于治疗移植物抗宿主病(GVHD)、多种自身免疫性疾病和器官移植排斥反应。ECP利用凋亡细胞被受者的未成熟树突状细胞(imDC)吞噬后,可以抑制树突状细胞(DC)成熟的原理,进而诱导负向免疫调节。ECP作为一种新的细胞免疫疗法,在不增加移植受者感染发生率的基础上可明显减轻免疫抑制剂的不良反应,其使用安全性高且应用范围广泛,在临床应用中有广阔的前景。本文就ECP的原理、ECP在器官移植排斥反应中的应用及ECP的分子机制作一综述。

     

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出版历程
  • 收稿日期:  2019-06-17
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2019-09-15

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