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ABO血型不合活体肾移植11例分析

汪昶 陈立中 邱江 张锦 吴子玄 陈国栋

汪昶, 陈立中, 邱江, 等. ABO血型不合活体肾移植11例分析[J]. 器官移植, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011
引用本文: 汪昶, 陈立中, 邱江, 等. ABO血型不合活体肾移植11例分析[J]. 器官移植, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011
Wang Chang, Chen Lizhong, Qiu Jiang, et al. Analysis of 11 cases of ABO incompatible living kidney transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011
Citation: Wang Chang, Chen Lizhong, Qiu Jiang, et al. Analysis of 11 cases of ABO incompatible living kidney transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(2): 182-186. doi: 10.3969/j.issn.1674-7445.2019.02.011

ABO血型不合活体肾移植11例分析

doi: 10.3969/j.issn.1674-7445.2019.02.011
基金项目: 

国家自然科学基金 81470976

高校基本业务青年培育 14ykpy11

详细信息
    作者简介:

    汪昶,男,1992年生,博士,研究方向为移植免疫,Email:386989699@qq.com

    通讯作者:

    陈国栋,男,1979年生,博士,副教授,副主任医师,研究方向为移植免疫,Email:chenguodong2000@163.com

  • 中图分类号: R617

Analysis of 11 cases of ABO incompatible living kidney transplantation

More Information
  • 摘要:   目的  探讨ABO血型不合活体肾移植(ABOi-KT)的疗效和安全性。  方法  回顾性分析11例ABOi-KT的供、受体临床资料。受体术前均经过脱敏治疗,术后监测ABOi-KT受体的肾功能和血型抗体滴度恢复情况,观察ABOi-KT术后受体的并发症发生情况及预后情况。  结果  ABOi-KT术后11例受体血清肌酐(Scr)均恢复良好,未出现移植肾功能恢复延迟。其中2例受体分别在术后14、45 d出现Scr明显升高,1例受体术后出现临界性细胞性排斥反应,1例受体在术后33 d出现Scr升高,伴血型抗体滴度上升,经治疗后病情均平稳。其余7例受体术后移植肾功能正常,术后血型抗体滴度均无反弹。随访至2018年11月,未出现受体死亡和移植肾失功,受体及移植肾存活率均为100%。其中3例受体术后发生并发症,分别为肺部感染、BK病毒尿症和粒细胞缺乏症,经对症治疗后均痊愈。  结论  ABOi-KT安全可行且长期疗效较好,可以增加活体供肾的来源,缓解供肾来源短缺。

     

  • 图  1  ABOi-KT术后Scr水平和抗体滴度的变化

    Figure  1.  Change of Scr level and antibody titer of recipients after ABOi-KT

    图  2  ABOi-KT术后受体移植肾病理检查图片

    (苏木素-伊红,×400)

    Figure  2.  Pathological photographs of recipients after ABOi-KT

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出版历程
  • 收稿日期:  2019-01-08
  • 网络出版日期:  2021-04-27
  • 刊出日期:  2019-03-15

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