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MicroRNA在糖尿病诊断和胰岛移植物监测中的研究进展

王西亮 蔡志明 牟丽莎

王西亮, 蔡志明, 牟丽莎. MicroRNA在糖尿病诊断和胰岛移植物监测中的研究进展[J]. 器官移植, 2018, 9(1): 79-82. doi: 10.3969/j.issn.1674-7445.2018.01.012
引用本文: 王西亮, 蔡志明, 牟丽莎. MicroRNA在糖尿病诊断和胰岛移植物监测中的研究进展[J]. 器官移植, 2018, 9(1): 79-82. doi: 10.3969/j.issn.1674-7445.2018.01.012
Wang Xiliang, Cai Zhiming, Mou Lisha. Research progress of microRNA in diagnosis of diabetes mellitus and monitoring of islet transplant allograft[J]. ORGAN TRANSPLANTATION, 2018, 9(1): 79-82. doi: 10.3969/j.issn.1674-7445.2018.01.012
Citation: Wang Xiliang, Cai Zhiming, Mou Lisha. Research progress of microRNA in diagnosis of diabetes mellitus and monitoring of islet transplant allograft[J]. ORGAN TRANSPLANTATION, 2018, 9(1): 79-82. doi: 10.3969/j.issn.1674-7445.2018.01.012

MicroRNA在糖尿病诊断和胰岛移植物监测中的研究进展

doi: 10.3969/j.issn.1674-7445.2018.01.012
基金项目: 

国家重点研发计划 2017YFC1103704

深圳市“医疗卫生三名工程” SZSM201412020

深圳市医学高水平学科建设 2016031638

深圳市科技计划 JCJY20160229204849975

深圳市科技计划 GJHZ20170314171357556

深圳市卫生计生系统科研项目 SZXJ2017021

详细信息
    作者简介:

    王西亮,男,1987年生,博士,博士后,研究方向为基因组学,Email: taigongyu 271203@163.com

    通讯作者:

    牟丽莎,女,1983年生,博士,副研究员,研究方向为异种移植,Email: lishamou@gmail.com

  • 中图分类号: R587.1, R322.5+7, R977.1+5

Research progress of microRNA in diagnosis of diabetes mellitus and monitoring of islet transplant allograft

  • 摘要: 糖尿病已成为世界上继肿瘤、心脑血管疾病之后的严重慢性病,严重威胁人类健康。其发病原因是由于胰岛素分泌相对或绝对不足引发的糖代谢紊乱,并最终导致全身多器官损害。微小核糖核酸(miRNA)是在转录后水平调节基因表达的一类短小的非编码RNA,miRNA与糖尿病、胰岛β细胞功能以及胰岛素的分泌密切相关。miRNA稳定地存在于多种体液中,糖尿病患者血液中可检测到异常表达的miRNA,miRNA可应用于临床作为监测β细胞功能、糖尿病及胰岛移植物功能的新标志物。

     

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出版历程
  • 收稿日期:  2017-10-10
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-01-15

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