小肠移植受者长期疗效影响因素及其监控防治

王勉; 陈冬利; 吴国生; 赵青川

doi:10.3969/j.issn.1674-7445.2017.04.018

小肠移植受者长期疗效影响因素及其监控防治

doi: 10.3969/j.issn.1674-7445.2017.04.018

710032 西安, 第四军医大学西京消化病医院消化外科

基金项目:

国家自然科学基金面上项目 81570588

详细信息

通讯作者:
赵青川, Email：zhaoqc@fmmu.edu.cn

中图分类号: R617, R392.4
计量
- 文章访问数: 169
- HTML全文浏览量: 85
- PDF下载量: 8
- 被引次数: 0
出版历程
- 收稿日期: 2017-05-10
- 网络出版日期: 2021-01-19
- 刊出日期: 2017-07-15

摘要

摘要: 近些年来, 随着外科技术的发展和新型免疫抑制剂的出现, 小肠移植术成为治疗各种原因所致短肠综合征及不可逆性肠功能衰竭的首选手段之一。然而, 由于小肠本身为固有的高免疫原性、有菌的空腔器官等因素, 小肠移植术后长期疗效不甚理想。移植术后急、慢性排斥反应和感染等仍是影响患者长期存活的主要因素。随着对移植免疫反应的深入了解, 体液免疫因素在移植术后急、慢性排斥反应中的作用受到了人们的关注, 供体特异性抗体（DSA）与小肠移植后急、慢性排斥反应的发生发展密切相关。小肠移植术后长期疗效有赖于对排斥反应、感染等因素的有效监控防治及免疫耐受的形成。
- 小肠移植 /
- 抗体介导的排斥反应 /
- 供体特异性抗体（DSA） /
- 嵌合现象 /
- 移植物抗宿主病（GVHD） /
- 感染 /
- 移植后淋巴组织增生性疾病（PTLD）

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参考文献(20)

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