-
摘要: 自然杀伤(NK)细胞是机体免疫系统的重要组成部分, 在抗病毒感染免疫、肿瘤免疫、器官移植的排斥反应以及在免疫的调节中起着十分重要的作用。长期以来的研究表明, NK细胞并不是一个均一的细胞群体, 根据表面标志和功能的不同, 可以将NK细胞分为不同的亚群。在某些疾病的发生过程中, 如肿瘤、自身免疫性疾病等, 会导致NK细胞亚群的比例、表型改变和功能降低, 因此深入了解机体内NK细胞不同亚群的表型和功能特征, 从而明确其在疾病发生发展中的作用, 对揭示疾病的机制及早期发现疾病、判断预后、发现新的以NK细胞为靶点的免疫治疗措施, 具有重要意义。
-
[1] Hadad U, Martinez O, Krams SM. NK cells after transplantation: friend or foe[J]. Immunol Res, 2014, 58(2-3): 259-267. DOI: 10.1007/s12026-014-8493-4. [2] 魏海明, 田志刚. NK细胞的发育分化与功能极化[J].中国免疫学杂志, 2014, 30(1): 14-17. DOI: 10.3969/j.issn.1000-484X.2014.01.002.Wei HM, Tian ZG. Development, differentiation and functions of NK cells[J]. Chin J Immunol, 2014, 30(1): 14-17. DOI: 10.3969/j.issn.1000-484X.2014.01.002. [3] Ni F, Sun R, Fu B, et al. IGF-1 promotes the development and cytotoxic activity of human NK cells[J]. Nat Commun, 2013, 4:1479. DOI: 10.1038/ncomms2484. [4] 石炳毅.自然杀伤细胞在移植免疫中的双重作用[J].器官移植, 2011, 2(6): 301-303. DOI: 10.3969/j.issn.1674-7445.2011.06.001.Shi BY. Dual roles of natural killer cells in transplantation immunity[J]. Organ Transplant, 2011, 2(6): 301-303. DOI: 10.3969/j.issn.1674-7445.2011.06.001. [5] Ishida F, Kwong YL. Diagnosis and management of natural killer-cell malignancies[J]. Expert Rev Hematol, 2010, 3(5): 593-602. DOI: 10.1586/ehm.10.51. [6] Fu B, Tian Z, Wei H. Subsets of human natural killer cells and their regulatory effects[J]. Immunology, 2014, 141(4): 483-489. DOI: 10.1111/imm.12224. [7] Mace EM, Orange JS. Multiple distinct NK-cell synapses[J]. Blood, 2011, 118(25): 6475-6476. DOI: 10.1182/blood-2011-10-381392. [8] Croy BA, He H, Esadeg S, et al. Uterine natural killer cells: insights into their cellular and molecular biology from mouse modeling[J]. Reproduction, 2003, 126(2): 149-160. doi: 10.1530/rep.0.1260149 [9] Poqqi A, Zocchi MR. NK cell autoreactivity and autoimmune diseases[J]. Front Immunol, 2014, 5:27. DOI: 10.3389/fimmu.2014.00027. [10] Lang PA, Lang KS, Xu HC, et al. Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity[J]. Proc Natl Acad Sci U S A, 2012, 109(4): 1210-1215. DOI: 10.1073/pnas.1118834109. [11] Zimmerman MA, Martin A, Yee J, et al. Natural killer T cells in liver ischemia-reperfusion injury[J]. J Clin Med, 2017, 6(4): E41. DOI: 10.3390/jcm6040041. [12] Lin CM, Plenter RJ, Coulombe M, et al. Interferon gamma and contact-dependent cytotoxicity are each rate limiting for natural killer cell-mediated antibody-dependent chronic rejection[J]. Am J Transplant, 2016, 16(11): 3121-3130. DOI: 10.1111/ajt.13865. [13] Jewett A, Man YG, Tseng HC. Dual functions of natural killer cells in selection and differentiation of stem cells; role in regulation of inflammation and regeneration of tissues[J]. J Cancer, 2013, 4(1): 12-24. DOI: 10.7150/jca.5519. [14] Xu Z, Jin B. A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions[J]. Cell Mol Immunol, 2010, 7(1): 11-19. DOI: 10.1038/cmi.2009.108. [15] Verneris MR. Natural killer cells and regulatory T cells: how to manipulate a graft for optimal GVL[J]. Hematology Am Soc Hematol Educ Program, 2013: 335-341. DOI: 10.1182/asheducation-2013.1.335. [16] Thordardottir S, Schaap N, Louer E, et al. Hematopoietic stem cell-derived myeloid and plasmacytoid DC-based vaccines are highly potent inducers of tumor-reactive T cell and NK cell responses ex vivo[J]. Oncoimmunology, 2017, 6(3): e1285991. DOI: 10.1080/2162402X.2017.1285991. [17] Chijioke O, Münz C. Dendritic cell derived cytokines in human natural killer cell differentiation and activation[J]. Front Immunol, 2013, 4:365. DOI: 10.3389/fimmu.2013.00365. [18] 石炳毅.自然杀伤细胞在器官移植排斥反应和免疫耐受中的作用[J].中华器官移植杂志, 2011, 32(10): 581-583. DOI: 10.3760/cma.j.issn.0254-1785.2011.10.001.Shi BY. The role of natural killer cells in organ transplantation rejection and immune tolerance[J]. Chin J Organ Transplant, 2011, 32(10): 581-583. DOI: 10.3760/cma.j.issn.0254-1785.2011.10.001. [19] López-Botet M, Vilches C, Redondo-Pachón D, et al. Dual role of natural killer cells on graft rejection and control of cytomegalovirus infection in renal transplantation[J]. Front Immunol, 2017, 8:166. DOI: 10.3389/fimmu.2017.00166. [20] Wood KJ, Bushell A, Hester J. Regulatory immune cells in transplantation [J]. Nat Rev Immunol, 2012, 12(6): 417-430. DOI: 10.1038/nri3227.
点击查看大图
计量
- 文章访问数: 442
- HTML全文浏览量: 254
- PDF下载量: 38
- 被引次数: 0