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异基因造血干细胞移植后人巨细胞病毒再激活的主要分子事件

韦爱萍, 宋雅琴, 周秀英, 等. 异基因造血干细胞移植后人巨细胞病毒再激活的主要分子事件[J]. 器官移植, 2022, 13(4): 522-529. doi: 10.3969/j.issn.1674-7445.2022.04.017
引用本文: 韦爱萍, 宋雅琴, 周秀英, 等. 异基因造血干细胞移植后人巨细胞病毒再激活的主要分子事件[J]. 器官移植, 2022, 13(4): 522-529. doi: 10.3969/j.issn.1674-7445.2022.04.017
Wei Aiping, Song Yaqin, Zhou Xiuying, et al. Major molecular events of reactivation of human cytomegalovirus after allogeneic hematopoietic stem cell transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 522-529. doi: 10.3969/j.issn.1674-7445.2022.04.017
Citation: Wei Aiping, Song Yaqin, Zhou Xiuying, et al. Major molecular events of reactivation of human cytomegalovirus after allogeneic hematopoietic stem cell transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(4): 522-529. doi: 10.3969/j.issn.1674-7445.2022.04.017

异基因造血干细胞移植后人巨细胞病毒再激活的主要分子事件

doi: 10.3969/j.issn.1674-7445.2022.04.017
基金项目: 

贵州省卫生健康委员会科学技术基金 gzwjkj2019-1-106

广东省医学科学技术研究基金 B2019217

详细信息
    作者简介:
    通讯作者:

    谢政军,男,1971年生,医学博士,副主任医师,研究方向为造血干细胞移植及移植后感染控制、细胞免疫治疗,Email:zhj_xie@hotmail.com

  • 中图分类号: R617, R373

Major molecular events of reactivation of human cytomegalovirus after allogeneic hematopoietic stem cell transplantation

More Information
  • 摘要: 异基因造血干细胞移植(allo-HSCT)所致的机体免疫缺陷是引起潜伏状态人巨细胞病毒(HCMV)再激活的始动因素。allo-HSCT受者HCMV再激活的危险因素包括供受者HCMV血清学状况、人类白细胞抗原(HLA)匹配程度及预处理方式等。HCMV再激活与病毒基因组中主要即刻早期启动子/增强子(MIEP)过表达诱发的系列病毒裂解增殖蛋白的表达相关。本文就引起allo-HSCT术后HCMV再激活的危险因素、维持HCMV潜伏感染相关的分子变化、MIEP过表达在HCMV再激活过程中的关键作用、参与allo-HSCT术后HCMV再激活的分子通路进行综述,探讨allo-HSCT后HCMV再激活的主要分子事件,为allo-HSCT后巨细胞病毒病(CMVD)的防治提供参考。

     

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  • 收稿日期:  2022-02-06
  • 网络出版日期:  2022-07-14
  • 刊出日期:  2022-07-15

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