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肾移植免疫诱导方案临床应用进展

何龙 王博谦

何龙, 王博谦. 肾移植免疫诱导方案临床应用进展[J]. 器官移植, 2021, 12(6): 682-686. doi: 10.3969/j.issn.1674-7445.2021.06.006
引用本文: 何龙, 王博谦. 肾移植免疫诱导方案临床应用进展[J]. 器官移植, 2021, 12(6): 682-686. doi: 10.3969/j.issn.1674-7445.2021.06.006
He Long, Wang Boqian. Clinical application progress of immune induction regimen for kidney transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 682-686. doi: 10.3969/j.issn.1674-7445.2021.06.006
Citation: He Long, Wang Boqian. Clinical application progress of immune induction regimen for kidney transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 682-686. doi: 10.3969/j.issn.1674-7445.2021.06.006

肾移植免疫诱导方案临床应用进展

doi: 10.3969/j.issn.1674-7445.2021.06.006
基金项目: 

辽宁省民生科技计划 2021JH2/10300089

详细信息
    作者简介:

    何龙,副主任医师,医学博士后,硕士研究生导师。现任中国人民解放军北部战区总医院器官移植中心副主任。兼任中国医疗保健国际交流促进会器官移植学分会委员、全军器官移植学会委员、中华医学会器官移植学分会青年委员、辽宁省医学会器官移植学分会委员。兼任《器官移植》杂志通讯编委。主持国家及省部级科研基金7项,在国内外杂志发表学术论文40余篇,主编专著3部,拥有国家专利3项

    通讯作者:

    何龙,Email:helongyh@vip.qq.com

  • 中图分类号: R617, R392.4

Clinical application progress of immune induction regimen for kidney transplantation

More Information
  • 摘要: 随着免疫抑制剂的发展和免疫抑制方案的优化,肾移植受者和移植物的存活率显著提高,术后急性排斥反应发生率和移植物功能延迟恢复发生率也明显降低。但是标准的三联免疫抑制方案(钙调磷酸酶抑制剂+ 抗代谢药物+ 糖皮质激素)仍无法有效控制移植肾排斥反应,因此提出在移植前进行免疫诱导方案。免疫诱导治疗可推迟钙调磷酸酶抑制剂的应用时间,降低其使用剂量,减少术后短期急性排斥反应的发生,改善受者中远期预后。本文将从单克隆抗体为主的免疫诱导方案、多克隆抗体为主的免疫诱导方案以及间充质干细胞为主的免疫诱导方案进行探讨,以期为优化肾移植选择免疫诱导方案提供参考。

     

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出版历程
  • 收稿日期:  2021-08-18
  • 刊出日期:  2021-11-15

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