Research progress on liver transplantation for drug-induced liver injury

Wang Yanwei; Liang Yurong

doi:10.3969/j.issn.1674-7445.2022.03.009

Volume 13 Issue 3

May 2022

Turn off MathJax

Article Contents

Article Navigation > ORGAN TRANSPLANTATION > 2022 > 13(3): 338-343

Wang Yanwei, Liang Yurong. Research progress on liver transplantation for drug-induced liver injury[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 338-343. doi: 10.3969/j.issn.1674-7445.2022.03.009

Citation:

Wang Yanwei, Liang Yurong. Research progress on liver transplantation for drug-induced liver injury[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 338-343. doi: 10.3969/j.issn.1674-7445.2022.03.009

Citation:

Wang Yanwei, Liang Yurong. Research progress on liver transplantation for drug-induced liver injury[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 338-343. doi: 10.3969/j.issn.1674-7445.2022.03.009

PDF( 5837 KB)

Research progress on liver transplantation for drug-induced liver injury

doi: 10.3969/j.issn.1674-7445.2022.03.009

Wang Yanwei,
Liang Yurong^,

Faculty of Hepato-Pancreato-Biliary Surgery, the First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China

More Information

Corresponding author: Liang Yurong, Email: yurongliang@hotmail.com
Received Date: 2022-01-24
Available Online: 2022-04-29
Publish Date: 2022-05-15

Abstract

Abstract

Drug-induced liver injury (DILI) is a type of necrotizing and inflammatory liver disease caused by certain commonly-used drugs, Chinese herbal medicines or dietary supplements. In severe cases, it may lead to acute liver failure. Without liver transplantation, the fatality could reach up to 80%. It is of significance to master the indications of liver transplantation. Several prognostic scoring systems have been developed to help clinicians to decide which patients need urgent liver transplantation, such as King's College criteria (KCC) and model for end-stage liver disease (MELD) scoring systems. However, these scoring methods have been developed for a long period of time and lack of modifications. Therefore, scholars have proposed several new scoring systems, such as acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) and sequential organ failure assessment (SOFA) scoring systems, which provide novel ideas for the evaluation of liver transplantation. As an important treatment measure for drug-induced acute liver failure, urgent liver transplantation has greatly improved the survival rate of patients. In this article, the classification, clinical diagnosis, liver transplantation evaluation and prognosis of DILI were summarized, aiming to provide reference for the treatment of DILI by liver transplantation.

FullText(HTML)

References(31)

References

[1]	寇晓彤, 李琦, 陈畅. 药物诱导的肝损伤研究现状[J]. 中国临床药理学杂志, 2021, 37(21): 2981-2984. DOI: 10.13699/j.cnki.1001-6821.2021.21.028. KOU XT, LI Q, CHEN C. Research progress of drug induced liver injury[J]. Chin J Clin Pharmacol, 2021, 37(21): 2981-2984. DOI: 10.13699/j.cnki.1001-6821.2021.21.028.
[2]	GERMANI G, BATTISTELLA S, ULINICI D, et al. Drug induced liver injury: from pathogenesis to liver transplantation[J]. Minerva Gastroenterol (Torino), 2021, 67(1): 50-64. DOI: 10.23736/S2724-5985.20.02795-6.
[3]	CHAYANUPATKUL M, SCHIANO TD. Acute liver failure secondary to drug-induced liver injury[J]. Clin Liver Dis, 2020, 24(1): 75-87. DOI: 10.1016/j.cld.2019.09.005.
[4]	杨婉娜, 谢雯. 药物性肝损伤的临床表现和分型[J]. 临床肝胆病杂志, 2021, 37(11): 2525-2529. DOI: 10.3969/j.issn.1001-5256.2021.11.004. YANG WN, XIE W. Clinical manifestations and typing of drug-induced liver injury[J]. J Clin Hepatol, 2021, 37(11): 2525-2529. DOI: 10.3969/j.issn.1001-5256.2021.11.004.
[5]	TILLMANN HL, ROCKEY DC. Signatures in drug-induced liver injury[J]. Curr Opin Gastroenterol, 2020, 36(3): 199-205. DOI: 10.1097/MOG.0000000000000636.
[6]	CHANG L, XU D, ZHU J, et al. Herbal therapy for the treatment of acetaminophen-associated liver injury: recent advances and future perspectives[J]. Front Pharmacol, 2020, 11: 313. DOI: 10.3389/fphar.2020.00313.
[7]	SIMMONS OL, MEINZER C, RULE J, et al. Liver transplantation for acetaminophen-induced acute liver failure: role of psychiatric comorbidity in listing decisions and outcomes[J]. Dig Dis Sci, 2020, 65(6): 1861-1868. DOI: 10.1007/s10620-019-05901-2.
[8]	HASSAN A, FONTANA RJ. The diagnosis and management of idiosyncratic drug-induced liver injury[J]. Liver Int, 2019, 39(1): 31-41. DOI: 10.1111/liv.13931.
[9]	GU R, LIANG A, LIAO G, et al. Roles of co-factors in drug-induced liver injury: drug metabolism and beyond[J]. Drug Metab Dispos, 2022, DOI: 10.1124/dmd.121.000457[Epub ahead of print].
[10]	AHMAD J, ODIN JA. Epidemiology and genetic risk factors of drug hepatotoxicity[J]. Clin Liver Dis, 2017, 21(1): 55-72. DOI: 10.1016/j.cld.2016.08.004.
[11]	于乐成, 茅益民, 陈成伟. 药物性肝损伤诊治指南[J]. 实用肝脏病杂志, 2017, 20(2): 257-274. DOI: 10.3969/j.issn.1672-5069.2017.02.039. YU LC, MAO YM, CHEN CW. Guidelines for diagnosis and treatment of drug-induced liver injury[J]. J Pract Hepatol, 2017, 20(2): 257-274. DOI: 10.3969/j.issn.1672-5069.2017.02.039.
[12]	马晓瑞, 李红霞, 马利. 348例药物性肝损害的临床分析[J]. 西安交通大学学报(医学版), 2021, 42(6): 909-914. DOI: 10.7652/jdyxb202106020. MA XR, LI HX, MA L. Clinical analysis of 348 cases of drug-induced liver damage[J]. J Xi'an Jiaotong Univ(Med Sci), 2021, 42(6): 909-914. DOI: 10.7652/jdyxb202106020.
[13]	GARCIA-CORTES M, ROBLES-DIAZ M, STEPHENS C, et al. Drug induced liver injury: an update[J]. Arch Toxicol, 2020, 94(10): 3381-3407. DOI: 10.1007/s00204-020-02885-1.
[14]	REAL M, BARNHILL MS, HIGLEY C, et al. Drug-induced liver injury: highlights of the recent literature[J]. Drug Saf, 2019, 42(3): 365-387. DOI: 10.1007/s40264-018-0743-2.
[15]	DELIRE B, DE MARTIN E, MEUNIER L, et al. Immunotherapy and gene therapy: new challenges in the diagnosis and management of drug-induced liver injury[J]. Front Pharmacol, 2022, 12: 786174. DOI: 10.3389/fphar.2021.786174.
[16]	丁超峰, 高晟, 郑树森. 药物性急性肝衰竭行肝移植治疗的预后因素探讨[J/CD]. 中华移植杂志(电子版), 2020, 14(4): 268-271. DOI: 10.3877/cma.j.issn.1674-3903.2020.04.017. DING CF, GAO S, ZHENG SS. Prognostic factors of liver transplantation for patients with drug induced acute liver failure[J/CD]. Chin J Transplant (Electr Edit), 2020, 14(4): 268-271. DOI: 10.3877/cma.j.issn.1674-3903.2020.04.017.
[17]	DONDORF F, CRONER RS, TAUTENHAHN HM, et al. Liver transplant due to flupirtine-induced acute liver failure[J]. Exp Clin Transplant, 2020, 18(4): 481-484. DOI: 10.6002/ect.2019.0297.
[18]	LEE JE, KWAK KH. A liver transplant recipient with possible bupivacaine-induced liver injury caused by intra-articular injection after total knee arthroplasty: a case report[J]. Medicine (Baltimore), 2018, 97(38): e12481. DOI: 10.1097/MD.0000000000012481.
[19]	YEBOAH-KORANG A, MEMON A, PATEL N, et al. Impact of prior drug allergies on the risk, clinical features, and outcomes of idiosyncratic drug-induced liver injury in adults[J]. Dig Dis Sci, 2022, DOI: 10.1007/s10620-022-07403-0[Epub ahead of print].
[20]	WEBER S, WOISCHKE C, DENK G, et al. Novel predictors for liver transplantation or death in drug-induced acute liver failure[J]. Eur J Gastroenterol Hepatol, 2022, 34(4): 422-425. DOI: 10.1097/MEG.0000000000002272.
[21]	MCPHAIL MJ, FARNE H, SENVAR N, et al. Ability of King's College criteria and model for end-stage liver disease scores to predict mortality of patients with acute liver failure: a Meta-analysis[J]. Clin Gastroenterol Hepatol, 2016, 14(4): 516-525. DOI: 10.1016/j.cgh.2015.10.007.
[22]	ANAND AC, NIGHTINGALE P, NEUBERGER JM. Early indicators of prognosis in fulminant hepatic failure: an assessment of the King's criteria[J]. J Hepatol, 1997, 26(1): 62-68. DOI: 10.1016/s0168-8278(97)80010-4.
[23]	KHANAM A, KOTTILIL S. Acute-on-chronic liver failure: pathophysiological mechanisms and management[J]. Front Med (Lausanne), 2021, 8: 752875. DOI: 10.3389/fmed.2021.752875.
[24]	KIM WR, MANNALITHARA A, HEIMBACH JK, et al. MELD 3.0: the model for end-stage liver disease updated for the modern era[J]. Gastroenterology, 2021, 161(6): 1887-1895. DOI: 10.1053/j.gastro.2021.08.050.
[25]	CHOLONGITAS E, THEOCHARIDOU E, VASIANOPOULOU P, et al. Comparison of the sequential organ failure assessment score with the King's College Hospital criteria and the model for end-stage liver disease score for the prognosis of acetaminophen-induced acute liver failure[J]. Liver Transpl, 2012, 18(4): 405-412. DOI: 10.1002/lt.23370.
[26]	BJÖRNSSON ES. Clinical management of patients with drug-induced liver injury (DILI)[J]. United European Gastroenterol J, 2021, 9(7): 781-786. DOI: 10.1002/ueg2.12113.
[27]	SÁEZ-GONZÁLEZ E, CONDE I, DÍAZ-JAIME FC, et al. Iberogast-induced severe hepatotoxicity leading to liver transplantation[J]. Am J Gastroenterol, 2016, 111(9): 1364-1365. DOI: 10.1038/ajg.2016.260.
[28]	MINDIKOGLU AL, MAGDER LS, REGEV A. Outcome of liver transplantation for drug-induced acute liver failure in the United States: analysis of the United Network for Organ Sharing database[J]. Liver Transpl, 2009, 15(7): 719-729. DOI: 10.1002/lt.21692.
[29]	BERNAL W, CROSS TJ, AUZINGER G, et al. Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience[J]. J Hepatol, 2009, 50(2): 306-313. DOI: 10.1016/j.jhep.2008.09.012.
[30]	DAWWAS MF, GIMSON AE, LEWSEY JD, et al. Survival after liver transplantation in the United Kingdom and Ireland compared with the United States[J]. Gut, 2007, 56(11): 1606-1613. DOI: 10.1136/gut.2006.111369.
[31]	AU KP, CHAN SC, CHOK KS, et al. Clinical factors affecting rejection rates in liver transplantation[J]. Hepatobiliary Pancreat Dis Int, 2015, 14(4): 367-373. DOI: 10.1016/s1499-3872(15)60391-5.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(1)

Get Citation

PDF

XML

Article Metrics

Article views (310) PDF downloads(94)

Research progress on liver transplantation for drug-induced liver injury

doi: 10.3969/j.issn.1674-7445.2022.03.009

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Research progress on liver transplantation for drug-induced liver injury

doi: 10.3969/j.issn.1674-7445.2022.03.009

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content