Diagnostic criteria and its progress on intestinal graft pathology

Guo Hui; Chen Zhishui

doi:10.3969/j.issn.1674-7445.2022.03.005

Volume 13 Issue 3

May 2022

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Guo Hui, Chen Zhishui. Diagnostic criteria and its progress on intestinal graft pathology[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 307-316. doi: 10.3969/j.issn.1674-7445.2022.03.005

Citation:

Guo Hui, Chen Zhishui. Diagnostic criteria and its progress on intestinal graft pathology[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 307-316. doi: 10.3969/j.issn.1674-7445.2022.03.005

Citation:

Guo Hui, Chen Zhishui. Diagnostic criteria and its progress on intestinal graft pathology[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 307-316. doi: 10.3969/j.issn.1674-7445.2022.03.005

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Diagnostic criteria and its progress on intestinal graft pathology

doi: 10.3969/j.issn.1674-7445.2022.03.005

Guo Hui,
Chen Zhishui^,

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China

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Corresponding author: Chen Zhishui, Email: zschen@tjh.tjmu.edu.cn
Received Date: 2022-03-21
Available Online: 2022-04-29
Publish Date: 2022-05-15

Abstract

Abstract

Intestinal transplantation has become the most ideal treatment for intestinal failure. Modern clinical intestinal transplantation includes three types: isolated intestinal transplantation, combined liver-intestinal transplantation and abdominal multivisceral transplantation. The immunological, anatomical and physiological characteristics of intestinal grafts significantly differ from those of other solid transplant organs. Consequently, intestinal grafts could develop specific and severe complications, such as acute rejection, chronic rejection, graft-versus-host disease (GVHD), infection and posttransplant lymphoproliferative disease (PTLD), among which acute rejection and infection are extremely challenging. Endoscopic examination and intestinal mucosal biopsy of intestinal grafts could be performed to make timely diagnosis and differentiation of these complications, then deliver targeted treatment and guarantee the long-term survival of recipients and intestinal grafts.

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References(34)

References

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Diagnostic criteria and its progress on intestinal graft pathology

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