Risk factors of multi-drug resistant organism infection after liver transplantation: a single-center clinical trial

Fang Yitian; Wu Ruolin; Huang Fan; Wang Guobin; Feng Lijuan; Yu Xiaojun; Hou Liujin; Ye Zhenghui; Geng Xiaoping; Zhao Hongchuan

doi:10.3969/j.issn.1674-7445.2021.02.010

Volume 12 Issue 2

Mar. 2021

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Article Navigation > ORGAN TRANSPLANTATION > 2021 > 12(2): 197-202

Fang Yitian, Wu Ruolin, Huang Fan, et al. Risk factors of multi-drug resistant organism infection after liver transplantation: a single-center clinical trial[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 197-202. doi: 10.3969/j.issn.1674-7445.2021.02.010

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Risk factors of multi-drug resistant organism infection after liver transplantation: a single-center clinical trial

doi: 10.3969/j.issn.1674-7445.2021.02.010

Organ Transplantation Center, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

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Corresponding author: Zhao Hongchuan, Email: zhc0117@sina.com
Received Date: 2020-10-25
Available Online: 2021-03-19
Publish Date: 2021-03-15

Abstract

Abstract

Objective To analyze the risk factors of multi-drug resistant organism (MDRO) infection after liver transplantation. Methods The clinical data of 77 recipients undergoing liver transplantation were retrospectively analyzed. According to the incidence of MDRO infection, all recipients were divided into the non-MDRO infection group (n=51) and MDRO infection group (n=26). The infection rate and strain distribution of MDRO in liver transplant recipients were summarized. The risk factors of MDRO infection in liver transplant recipients were identified. Clinical prognosis of all recipients was statistically compared between two groups. Results The infection rate of MDRO after liver transplantation was 34% (26/77), mainly carbapenem-resistant MDRO infection. The main sites of infection included lung, abdominal cavity and incision. Univariate analysis showed that postoperative tracheal intubation ≥48 h, length of intensive care unit (ICU) stay ≥72 h, length of hospital stay ≥30 d, re-operation, continuous renal replacement therapy (CRRT) and tacrolimus (Tac) blood concentration ≥15 ng/mL were the risk factors for MDRO infection after liver transplantation. Cox regression analysis indicated that postoperative tracheal intubation≥48 h, re-operation, CRRT and Tac blood concentration ≥15 ng/mL were the independent risk factors for MDRO infection after liver transplantation. The fatality in the MDRO infection group was significantly higher than that in the non-MDRO infection group [31%(8/26) vs. 10%(5/51), P=0.01]. Conclusions Postoperative tracheal intubation ≥48 h, re-operation, CRRT and Tac blood concentration ≥15 ng/mL may increase the risk of MDRO infection after liver transplantation and affect clinical prognosis of the recipients.
- Liver transplantation,
- Multi-drug resistant organism,
- Infection,
- Continuous renal replacement therapy,
- Carbapenem-resistant Klebsiella pneumoniae,
- Gram-positive bacteria,
- Gram-negative bacteria,
- Sepsis

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Risk factors of multi-drug resistant organism infection after liver transplantation: a single-center clinical trial

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