Volume 12 Issue 2
Mar.  2021
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Yuan Qiang, Shen Kaiwen, Zhang Ruibo, et al. Role of NLRP3 inflammasome and related inflammatory signaling pathways in renal ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 177-183. doi: 10.3969/j.issn.1674-7445.2021.02.007
Citation: Yuan Qiang, Shen Kaiwen, Zhang Ruibo, et al. Role of NLRP3 inflammasome and related inflammatory signaling pathways in renal ischemia-reperfusion injury[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 177-183. doi: 10.3969/j.issn.1674-7445.2021.02.007
shu

Role of NLRP3 inflammasome and related inflammatory signaling pathways in renal ischemia-reperfusion injury

doi: 10.3969/j.issn.1674-7445.2021.02.007

  • Guizhou Medical University, Guiyang 550004, China

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  • Corresponding author: Shen Jun, Email: shenjun@gmc.edu.cn
  • Received Date: 2020-12-20
    Available Online: 2021-03-19
  • Publish Date: 2021-03-15
    Abstract
  • Renal ischemia-reperfusion injury (IRI) commonly occurs in renal transplantation, which is an important pathophysiological process that causes acute renal failure and severely affects clinical prognosis of the recipients. Inflammatory response plays a critical role in the pathogenesis and pathological process of IRI. Activated NOD-like receptor protein 3(NLRP3) inflammasome can mediate the maturation and release of various pro-inflammatory cytokines, thereby regulating the inflammatory response and relevant cell functions. In this article, the mechanism underlying NLRP3 inflammasome and its related inflammatory signaling pathway in renal IRI were reviewed, aiming to provide novel ideas for clinical prevention and treatment of renal IRI.

     

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