Volume 12 Issue 2
Mar.  2021
Turn off MathJax
Article Contents
Article Navigation >  ORGAN TRANSPLANTATION  > 2021  >  12(2): 134-142
Guo Hui. Pathology of T cell-mediated rejection in renal allograft[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 134-142. doi: 10.3969/j.issn.1674-7445.2021.02.003
Citation: Guo Hui. Pathology of T cell-mediated rejection in renal allograft[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 134-142. doi: 10.3969/j.issn.1674-7445.2021.02.003
shu

Pathology of T cell-mediated rejection in renal allograft

doi: 10.3969/j.issn.1674-7445.2021.02.003

  • Organ Transplantation Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation of Ministry of Education, Key Laboratory of Organ Transplantation of National Health Commission of China, Key Laboratory of Organ Transplantation of Chinese Academy of Medical Sciences, Wuhan 430030, China

More Information
  • Corresponding author: Guo Hui, E-mail:zcguo@tjh.tjmu.edu.cn
  • Received Date: 2021-01-25
    Available Online: 2021-03-19
  • Publish Date: 2021-03-15
    Abstract
  • T cell-mediated rejection (TCMR) is one of the main mechanisms of rejection in organ transplantation, which is also the most common type of acute rejection.Based on Banff classification on allograft pathology (Banff classification) in 2019, TCMR can be divided into acute TCMR (aTCMR) and chronic active TCMR (caTCMR) according to the characteristics of immune lesions.In this article, the basic definition of TCMR, the research progress on TCMR pathology according to Banff classification for renal allograft, and the basic pathological changes and diagnostic grading of TCMR were reviewed, aiming to provide evidence for early identification, diagnosis and treatment of TCMR and prevent the progression of TCMR into caTCMR, thereby guarantying the long-term survival of both the renal allograft and recipient.

     

    • FullText(HTML)
  • loading
    • References(27)
  • [1]
    中华医学会器官移植学分会. 器官移植病理学临床技术操作规范(2019版)--总论与肾移植[J]. 器官移植, 2019, 10(2): 128-141. DOI: 10.3969/j.issn.1674-7445.2019.02.004.

    Branch of Organ Transplantation of Chinese Medical Association. Clinical technical operation specification for pathology of organ transplantation (2019 edition): general introduction and kidney transplantation[J]. Organ Transplant, 2019, 10(2): 128-141. DOI: 10.3969/j.issn.1674-7445.2019.02.004.
    [2]
    陈实, 郭晖. 移植病理学[M]. 北京: 人民卫生出版社, 2009.
    [3]
    LOUPY A, HAAS M, ROUFOSSE C, et al. The Banff 2019 kidney meeting report (I): updates on and clarification of criteria for T cell-and antibody-mediated rejection[J]. Am J Transplant, 2020, 20(9): 2318-2331. DOI: 10.1111/ajt.15898.
    [4]
    SOLEZ K, AXELSEN RA, BENEDIKTSSON H, et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology[J]. Kidney Int, 1993, 44(2): 411-422. DOI: 10.1038/ki.1993.259.
    [5]
    SOLEZ K, BENEDIKTSSON H, CAVALLO T, et al. Report of the third Banff conference on allograft pathology (July 20-24, 1995) on classification and lesion scoring in renal allograft pathology[J]. Transplant Proc, 1996, 28(1): 441-444. http://europepmc.org/abstract/med/8644308
    [6]
    RACUSEN LC, SOLEZ K, COLVIN RB, et al. The Banff 97 working classification of renal allograft pathology[J]. Kidney Int, 1999, 55(2): 713-723. DOI: 10.1046/j.1523-1755.1999.00299.x.
    [7]
    SOLEZ K. History of the Banff classification of allograft pathology as it approaches its 20th year[J]. Curr Opin Organ Transplant, 2010, 15(1): 49-51. DOI: 10.1097/MOT.0b013e328334fedb.
    [8]
    SOLEZ K, COLVIN RB, RACUSEN LC, et al. Banff'05 meeting report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN')[J]. Am J Transplant, 2007, 7(3): 518-526. DOI: 10.1111/j.1600-6143.2006.01688.x.
    [9]
    SOLEZ K, COLVIN RB, RACUSEN LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions[J]. Am J Transplant, 2008, 8(4): 753-760. DOI: 10.1111/j.1600-6143.2008.02159.x.
    [10]
    BURDICK JF, BESCHORNER WE, SMITH WJ, et al. Characteristics of early routine renal allograft biopsies[J]. Transplantation, 1984, 38(6): 679-684. DOI: 10.1097/00007890-198412000-00026.
    [11]
    OLSEN S, BURDICK JF, KEOWN PA, et al. Primary acute renal failure ("acute tubular necrosis") in the transplanted kidney: morphology and pathogenesis[J]. Medicine (Baltimore), 1989, 68(3): 173-187. DOI: 10.1097/00005792-198905000-00005.
    [12]
    BATES WD, DAVIES DR, WELSH K, et al. An evaluation of the Banff classification of early renal allograft biopsies and correlation with outcome[J]. Nephrol Dial Transplant, 1999, 14(10): 2364-2369. DOI: 10.1093/ndt/14.10.2364.
    [13]
    ISONIEMI H, TASKINEN E, HÄYRY P. Histological chronic allograft damage index accurately predicts chronic renal allograft rejection[J]. Transplantation, 1994, 58(11): 1195-1198. doi: 10.1097/00007890-199412150-00010
    [14]
    SOLEZ K, RACUSEN LC. The Banff classification revisited[J]. Kidney Int, 2013, 83(2): 201-206. DOI: 10.1038/ki.2012.395.
    [15]
    LOUPY A, HAAS M, SOLEZ K, et al. The Banff 2015 kidney meeting report: current challenges in rejection classification and prospects for adopting molecular pathology[J]. Am J Transplant, 2017, 17(1): 28-41. DOI: 10.1111/ajt.14107.
    [16]
    NIN M, COITIÑO R, KURDIAN M, et al. Acute antibody-mediated rejection in kidney transplant based on the 2013 Banff criteria: single-center experience in Uruguay[J]. Transplant Proc, 2016, 48(2): 612-615. DOI: 10.1016/j.transproceed.2016.03.019.
    [17]
    SHIMIZU T, ISHIDA H, HAYAKAWA N, et al. Clinical and pathological analyses of cases of acute vascular rejection after kidney transplantation[J]. Transplant Proc, 2017, 49(10): 2251-2255. DOI: 10.1016/j.transproceed.2017.09.046.
    [18]
    HAAS M, LOUPY A, LEFAUCHEUR C, et al. The Banff 2017 kidney meeting report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials[J]. Am J Transplant, 2018, 18(2): 293-307. DOI: 10.1111/ajt.14625.
    [19]
    黄亚冰, 郭晖, 钟伟雄. 2017年Banff移植病理学会议纪要及移植肾病理诊断分类修订[J]. 中华器官移植杂志, 2018, 39(9): 565-570. DOI: 10.3760/cma.j.issn.0254-1785.2018.09.011.

    HUANG YB, GUO H, ZHONG WX. 2017 Banff allograft pathology conference summary and revised classification of transplant kidney pathology[J]. Chin J Organ Transplant, 2018, 39(9): 565-570. DOI: 10.3760/cma.j.issn.0254-1785.2018.09.011.
    [20]
    PASCUAL J, PÉREZ-SÁEZ MJ, MIR M, et al. Chronic renal allograft injury: early detection, accurate diagnosis and management[J]. Transplant Rev (Orlando), 2012, 26(4): 280-290. http://europepmc.org/abstract/MED/22902496
    [21]
    WILSON PC, KASHGARIAN M, MOECKEL G.Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis[J].Clin Kidney J, 2018, 11(2): 207-218.DOI: 10.1093/ckj/sfx093.
    [22]
    MENGEL M, REEVE J, BUNNAG S, et al.Scoring total inflammation is superior to the current Banff inflammation score in predicting outcome and the degree of molecular disturbance in renal allografts[J].Am J Transplant, 2009, 9(8): 1859-1867.DOI: 10.1111/j.1600-6143.2009.02727.x.
    [23]
    MANNON RB, MATAS AJ, GRANDE J, et al.Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure[J].Am J Transplant, 2010, 10(9): 2066-2073.DOI: 10.1111/j.1600-6143.2010.03240.x.
    [24]
    HUESO M, NAVARRO E, MORESO F, et al.Intragraft expression of the IL-10 gene is up-regulated in renal protocol biopsies with early interstitial fibrosis, tubular atrophy, and subclinical rejection[J].Am J Pathol, 2010, 176(4): 1696-1704.DOI: 10.2353/ajpath.2010.090411.
    [25]
    LEFAUCHEUR C, GOSSET C, RABANT M, et al.T cell-mediated rejection is a major determinant of inflammation in scarred areas in kidney allografts[J].Am J Transplant, 2018, 18(2): 377-390.DOI: 10.1111/ajt.14565.
    [26]
    NANKIVELL BJ, SHINGDE M, KEUNG KL, et al.The causes, significance and consequences of inflammatory fibrosis in kidney transplantation: the Banff i-IFTA lesion[J].Am J Transplant, 2018, 18(2): 364-376.DOI: 10.1111/ajt.14609.
    [27]
    LEFAUCHEUR C, VIGLIETTI D, LOUPY A.Recognition of i-IF/TA as a component of the T cellmediated rejection spectrum: unselected population approach vs random case selection[J].Am J Transplant, 2018, 18(3): 771-772.DOI: 10.1111/ajt.14667.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(6)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1020) PDF downloads(212) Cited by()
    Proportional views
    Related

    WeChat Subscription Account

    Wechat Service Account

    Contact Us
    • Tel：020-38736410
    • Email: organtranspl@163.com
    • Address：The Third Affiliated Hospital of Sun Yat-sen University, No. 600, Tianhe Road, Tianhe District, Guangzhou
    • Editorial Office of Organ Transplantation  粤ICP备2021030844号
    Links

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return