留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肝移植手术技术的现状和展望

谢闰鹏 谷明旗 张凤博 姜洪池

谢闰鹏, 谷明旗, 张凤博, 等. 肝移植手术技术的现状和展望[J]. 器官移植, 2022, 13(1): 105-110. doi: 10.3969/j.issn.1674-7445.2022.01.016
引用本文: 谢闰鹏, 谷明旗, 张凤博, 等. 肝移植手术技术的现状和展望[J]. 器官移植, 2022, 13(1): 105-110. doi: 10.3969/j.issn.1674-7445.2022.01.016
Xie Runpeng, Gu Mingqi, Zhang Fengbo, et al. Current status and prospect of surgical technique of liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 105-110. doi: 10.3969/j.issn.1674-7445.2022.01.016
Citation: Xie Runpeng, Gu Mingqi, Zhang Fengbo, et al. Current status and prospect of surgical technique of liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(1): 105-110. doi: 10.3969/j.issn.1674-7445.2022.01.016

肝移植手术技术的现状和展望

doi: 10.3969/j.issn.1674-7445.2022.01.016
基金项目: 

国家科技支撑计划 2015BAI3B09

美国中华医学基金会(CMB)项目 08-894

详细信息
    作者简介:

    谢闰鹏,男,硕士研究生,研究方向为肝脏外科,Email:807196491@qq.com

    通讯作者:

    姜洪池,男,教授,主任医师,研究方向为肝脾外科,Email:jianghc@vip.163.com

  • 中图分类号: R617, R657.3

Current status and prospect of surgical technique of liver transplantation

More Information
  • 摘要: 随着终末期肝病患者数量逐年增加,肝移植手术作为有效治疗手段,其安全性和疗效是需要考虑的重要问题,肝移植技术也成为了新的研究热点。多年来,经过广大研究者们的不懈努力,肝移植技术在不断创新与发展,研究者们相继开展了劈离式肝移植、无缺血肝移植、异种肝移植、多米诺肝移植、肝切除联合Ⅱ~Ⅲ段部分肝移植的延期全肝切除、脾窝异位辅助性肝移植及磁吻合等肝移植技术,为扩大供者池、提高肝移植疗效、改善肝移植受者生活质量奠定了基础。本文就肝移植手术技术的探索与发展、创新与改进方面进行综述和展望,以期为肝移植的临床应用提供参考。

     

  • [1] 中华医学会器官移植学分会. 中国肝移植术操作规范(2019版)[J]. 临床肝胆病杂志, 2020, 36(1): 36-39. DOI: 10.3969/j.issn.1001-5256.2020.01.006.

    Chinese Society of Organ Transplantation, Chinese Medical Association. Operation standards for liver transplantation in China (version 2019)[J]. J Clin Hepatol, 2020, 36(1): 36-39. DOI: 10.3969/j.issn.1001-5256.2020.01.006.
    [2] 王俊楠, 孙志为, 陈业盛, 等. 异位辅助性肝移植的研究进展[J]. 生物医学, 2021, 11(2): 63-68. DOI: 10.12677/HJBM.2021.112009.

    WANG JN, SUN ZW, CHEN YS, et al. Research progress of heterotopic auxiliary liver transplantation[J]. Hans J Biomed, 2021, 11(2): 63-68. DOI: 10.12677/HJBM.2021.112009.
    [3] 吕子成, 张子杰, 乔子耘, 等. 辅助肝移植技术创新与展望[J]. 中国实用外科杂志, 2021, 41(9): 1073-1077. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK202109018.htm

    LYU ZC, ZHANG ZJ, QIAO ZY, et al. Innovation and prospect of auxiliary liver transplantation technology[J]. Chin J Pract Surg, 2021, 41(9): 1073-1077. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK202109018.htm
    [4] 夏穗生. 我国肝移植发展沿革史[J]. 中华肝胆外科杂志, 2011, 17(11): 873-875. DOI: 10.3760/cma.j.issn.1007-8118.2011.11.001.

    XIA SS. History of liver transplantation in China[J]. Chin J Hepatobiliary Surg, 2011, 17(11): 873-875. DOI: 10.3760/cma.j.issn.1007-8118.2011.11.001.
    [5] PICHLMAYR R, RINGE B, GUBERNATIS G, et al. Transplantation of a donor liver to 2 recipients (splitting transplantation)--a new method in the further development of segmental liver transplantation[J]. Langenbecks Arch Chir, 1988, 373(2): 127-130. doi: 10.1007/BF01262776
    [6] AZOULAY D, CASTAING D, ADAM R, et al. Split-liver transplantation for two adult recipients: feasibility and long-term outcomes[J]. Ann Surg, 2001, 233(4): 565-574. DOI: 10.1097/00000658-200104000-00013.
    [7] 范宁, 李志强, 郭源, 等. 公民逝世后器官捐献原位劈离式肝移植单中心经验[J/CD]. 中华移植杂志(电子版), 2017, 11(4): 216-220. DOI: 10.3877/cma.j.issn.1674-3903.2017.04.005.

    FAN N, LI ZQ, GUO Y, et al. In-suit split liver transplantation from donation after citizen's death in China: a single-center experience[J/CD]. Chin J Transplant (Electr Edit), 2017, 11(4): 216-220. DOI: 10.3877/cma.j.issn.1674-3903.2017.04.005.
    [8] 朱志军. 小肝综合征的防治策略与进展[J]. 中国普外基础与临床杂志, 2017, 24(8): 923-926. DOI: 10.7507/1007-9424.201707095.

    ZHU ZJ. Prevention and treatment strategy and progress of small-for-size syndrome[J]. Chin J Bases Clin Gen Surg, 2017, 24(8): 923-926. DOI: 10.7507/1007-9424.201707095.
    [9] IKEGAMI T, YOSHIZUMI T, HARIMOTO N, et al. Splenectomy as flow modulation strategy and risk factors of de novo portal vein thrombosis in adult-to-adult living donor liver transplantation[J]. Liver Transpl, 2019, 25(8): 1281-1283. DOI: 10.1002/lt.25494.
    [10] GUO HJ, WANG K, CHEN KC, et al. Middle hepatic vein reconstruction in adult right lobe living donor liver transplantation improves recipient survival[J]. Hepatobiliary Pancreat Dis Int, 2019, 18(2): 125-131. DOI: 10.1016/j.hbpd.2019.01.006.
    [11] ITO T, NAINI BV, MARKOVIC D, et al. Ischemia-reperfusion injury and its relationship with early allograft dysfunction in liver transplant patients[J]. Am J Transplant, 2021, 21(2): 614-625. DOI: 10.1111/ajt.16219.
    [12] 卢中山, 王伟, 钟自彪, 等. 肝脏缺血再灌注损伤干预措施的研究进展[J]. 中华肝胆外科杂志, 2019, 25(11): 871-874. DOI: 10.3760/cma.j.issn.1007-8118.2019.11.020.

    LU ZS, WANG W, ZHONG ZB, et al. Advances in intervention measures for hepatic ischemia-reperfusion injury[J]. Chin J Hepatobiliary Surg, 2019, 25(11): 871-874. DOI: 10.3760/cma.j.issn.1007-8118.2019.11.020.
    [13] 何晓顺, 鞠卫强, 朱泽斌. "无缺血"器官移植时代的来临与展望[J/CD]. 中华普通外科学文献(电子版), 2018, 12(2): 73-75. DOI: 10.3877/cma.j.issn.1674-0793.2018.02.001.

    HE XS, JU WQ, ZHU ZB. The coming and prospect of the era of "ischemia free" organ transplantation[J/CD]. Chin Arch Gen Surg (Electr Edit), 2018, 12(2): 73-75. DOI: 10.3877/cma.j.issn.1674-0793.2018.02.001.
    [14] SHAH JA, NAVARRO-ALVAREZ N, DEFAZIO M, et al. A bridge to somewhere: 25-day survival after pig-to-baboon liver xenotransplantation[J]. Ann Surg, 2016, 263(6): 1069-1071. DOI: 10.1097/SLA.0000000000001659.
    [15] LI T, JIANG H, LIU H, et al. Extracellular histones and xenotransplantation[J]. Xenotransplantation, 2020, 27(5): e12618. DOI: 10.1111/xen.12618.
    [16] LI T, LV Y, SUN R, et al. Incompatibility between recipient CD47 and donor SIRPα is not a key risk factor for thrombocytopenia or anemia following rat liver xenotransplantation in mice[J]. Xenotransplantation, 2021, 28(3): e12657. DOI: 10.1111/xen.12657.
    [17] ZHENG H, LIU T, LEI T, et al. Promising potentials of Tibetan macaques in xenotransplantation[J]. Xenotransplantation, 2019, 26(1): e12489. DOI: 10.1111/xen.12489.
    [18] FURTADO AJ. Domino liver transplantation using FAP grafts. HUC experience--hopes and realities[J]. Amyloid, 2003, 10(Suppl 1): 84-87. http://www.paramiloidose.com.br/uploads/20030000%20Transplantacao%20de%20figado%20usando%20enxertos%20de%20portadores%20de%20PAF.%20Experiencia%20do%20Hospital%20Universitario%20de%20Coimbra.%202003.pdf
    [19] CELIK N, KELLY B, SOLTYS K, et al. Technique and outcome of domino liver transplantation from patients with maple syrup urine disease: expanding the donor pool for live donor liver transplantation[J]. Clin Transplant, 2019, 33(11): e13721. DOI: 10.1111/ctr.13721.
    [20] LERUT J, FOGUENNE M, LAI Q, et al. Domino-liver transplantation: toward a safer and simpler technique in both donor and recipient[J]. Updates Surg, 2021, 73(1): 223-232. DOI: 10.1007/s13304-020-00886-4.
    [21] QU W, WEI L, ZHU ZJ, et al. Considerations for use of domino cross-auxiliary liver transplantation in metabolic liver diseases: a review of case studies[J]. Transplantation, 2019, 103(9): 1916-1920. DOI: 10.1097/TP.0000000000002602.
    [22] MARQUES HP, BARROS I, LI J, et al. Current update in domino liver transplantation[J]. Int J Surg, 2020, 82(Suppl): 163-168. DOI: 10.1016/j.ijsu.2020.03.017.
    [23] LINE PD, HAGNESS M, BERSTAD AE, et al. A novel concept for partial liver transplantation in nonresectable colorectal liver metastases: the RAPID concept[J]. Ann Surg, 2015, 262(1): e5-e9. DOI: 10.1097/SLA.0000000000001165.
    [24] BALCI D, KIRIMKER EO, BINGOL KOLOGLU M, et al. A new approach for increasing availability of liver grafts and donor safety in living donor liver transplantation: LD-RAPID procedure in the cirrhotic setting with hepatocellular carcinoma[J]. Liver Transpl, 2021, 27(4): 590-594. DOI: 10.1002/lt.25855.
    [25] KÖNIGSRAINER A, TEMPLIN S, CAPOBIANCO I, et al. Paradigm shift in the management of irresectable colorectal liver metastases: living donor auxiliary partial orthotopic liver transplantation in combination with two-stage hepatectomy (LD-RAPID)[J]. Ann Surg, 2019, 270(2): 327-332. DOI: 10.1097/SLA.0000000000002861.
    [26] KROMREY ML, ITTERMANN T, VWAHSEN C, et al. Reference values of liver volume in Caucasian population and factors influencing liver size[J]. Eur J Radiol, 2018, 106: 32-37. DOI: 10.1016/j.ejrad.2018.07.005.
    [27] LIM C, SCATTON O. Living donor liver transplantation using the RAPID technique in the cirrhotic setting is still in its developmental stage[J]. Liver Transpl, 2021, 27(5): 772-774. DOI: 10.1002/lt.25971.
    [28] RAVAIOLI M, FALLANI G, CESCON M, et al. Heterotopic auxiliary segment 2-3 liver transplantation with delayed total hepatectomy: new strategies for nonresectable colorectal liver metastases[J]. Surgery, 2018, 164(3): 601-603. DOI: 10.1016/j.surg.2018.05.021.
    [29] RAVAIOLI M, BRANDI G, SINISCALCHI A, et al. Heterotopic segmental liver transplantation on splenic vessels after splenectomy with delayed native hepatectomy after graft regeneration: a new technique to enhance liver transplantation[J]. Am J Transplant, 2021, 21(2): 870-875. DOI: 10.1111/ajt.16222.
    [30] RAVAIOLI M, SERENARI M, CESCON M, et al. Liver and vena cava en bloc resection for an invasive leiomyosarcoma causing budd-chiari syndrome, under veno-venous bypass and liver hypothermic perfusion : liver hypothermic perfusion and veno-venous bypass for inferior vena cava leiomyosarcoma[J]. Ann Surg Oncol, 2017, 24(2): 556-557. DOI: 10.1245/s10434-016-5285-1.
    [31] OBORA Y, TAMAKI N, MATSUMOTO S. Nonsuture microvascular anastomosis using magnet rings: preliminary report[J]. Surg Neurol, 1978, 9(2): 117-120. http://europepmc.org/abstract/MED/625696
    [32] LU Q, LIU K, ZHANG W, et al. End-to-end vascular anastomosis using a novel magnetic compression device in rabbits: a preliminary study[J]. Sci Rep, 2020, 10(1): 5981. DOI: 10.1038/s41598-020-62936-6.
    [33] 中华医学会外科学分会外科手术学学组. 关于利用磁力再通术治疗肝移植术后胆道吻合口狭窄的专家建议[J]. 器官移植, 2020, 11(1): 13-18. DOI: 10.3969/j.issn.1674-7445.2020.01.003.

    Operative Surgery Group of Branch of Surgery of Chinese Medical Association. Expert recommendation on magnetic recanalization for the treatment of biliary anastomosis stricture after liver transplantation[J]. Organ Transplant, 2020, 11(1): 13-18. DOI: 10.3969/j.issn.1674-7445.2020.01.003.
    [34] LI Y, SUN H, YAN X, et al. Magnetic compression anastomosis for the treatment of benign biliary strictures: a clinical study from China[J]. Surg Endosc, 2020, 34(6): 2541-2550. DOI: 10.1007/s00464-019-07063-8.
    [35] 刘仕琪, 吕毅, 宋宇龙, 等. 磁吻合技术实现犬腹主动脉快速无缝线吻合实验研究[J]. 中华血管外科杂志, 2021, 6(1): 38-42. DOI: 10.3760/cma.j.cn101411-20200515-00050.

    LIU SQ, LYU Y, SONG YL, et al. Experimental animal study of rapid and sutureless anastomosis of abdominal aorta by the magnetic compression anastomosis technique[J]. Chin J Vasc Surg, 2021, 6(1): 38-42. DOI: 10.3760/cma.j.cn101411-20200515-00050.
  • 加载中
图(1)
计量
  • 文章访问数:  241
  • HTML全文浏览量:  60
  • PDF下载量:  59
  • 被引次数: 0
出版历程
  • 收稿日期:  2021-09-22
  • 网络出版日期:  2022-01-12
  • 刊出日期:  2022-01-15

目录

    /

    返回文章
    返回